FAQ

GGA1 gene

Known as: golgi-associated, gamma adaptin ear containing, ARF binding protein 1, GGA1, ARF-BINDING PROTEIN 1 
 

Topic mentions per year

Topic mentions per year

1998-2018
051019982018

Papers overview

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2012
2012
Depletion of GGA1 and GGA3 mediates postinjury elevation of BACE1.
Traumatic brain injury (TBI) is one of the most robust environmental risk factors for Alzheimer's disease (AD). Compelling… (More)
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2008
2008
Arf1-GTP-induced tubule formation suggests a function of Arf family proteins in curvature acquisition at sites of vesicle budding.
ADP-ribosylation factor (Arf) and related small GTPases play crucial roles in membrane traffic within the exo- and endocytic… (More)
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2006
2006
Intracellular trafficking and secretion of adiponectin is dependent on GGA-coated vesicles.
Adiponectin (Acrp30) is an insulin-sensitizing hormone produced and secreted exclusively by adipose tissue. Confocal fluorescent… (More)
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2006
2006
GGA1 is expressed in the human brain and affects the generation of amyloid beta-peptide.
The beta-amyloid peptide (Abeta) is a major component of Alzheimer disease (AD)-associated senile plaques and is generated by… (More)
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Highly Cited
2005
Highly Cited
2005
GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network.
Golgi-localized, gamma ear-containing, ADP ribosylation factor-binding (GGA) proteins have been shown to be implicated in the… (More)
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2004
2004
Demonstration of BACE (beta-secretase) phosphorylation and its interaction with GGA1 in cells by fluorescence-lifetime imaging microscopy.
beta-Secretase (BACE) carries out the first of two proteolysis steps to generate the amyloid-beta peptides that accumulate in the… (More)
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2003
2003
Morphology and dynamics of clathrin/GGA1-coated carriers budding from the trans-Golgi network.
Sorting of transmembrane proteins and their ligands at various compartments of the endocytic and secretory pathways is mediated… (More)
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2003
2003
Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.
Memapsin 2 (beta-secretase) is a membrane-associated aspartic protease that initiates the hydrolysis of beta-amyloid precursor… (More)
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2002
2002
Memapsin 2 (beta-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2.
Memapsin 2, or beta-secretase, is a membrane-anchored aspartic protease that initiates the cleavage of beta-amyloid precursor… (More)
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2002
2002
The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding.
We report that the Vps10p domain receptor sorLA binds the adaptor proteins GGA1 and -2, which take part in Golgi-endosome sorting… (More)
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