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GE2270A

National Institutes of Health

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GE 2270 A

Papers overview

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2012
2012
New Methods for the Synthesis of Vicinal Stereocenters : Palladium-Catalyzed Domino Reactions and Asymmetric Transfer Hydrogenation
In this thesis the synthesis of vicinal stereocenters is investigated in two distinct contexts, namely the construction of 3,3… 
2010
2010
Etude de nouvelles méthodologies d'hétéroarylation directe de liaison C-Het C-Br en série thiazolique : application à la synthèse de coeurs thiazolylpyridiniques des thiopeptides de la série d
Face a l’apparition alarmante et continue de resistance massive des bacteries a l’arsenal actuel d’antibiotiques, la recherche de… 
2004
2004
Archaeal elongation factor 1α from Sulfolobus solfataricus interacts with the eubacterial antibiotic GE2270A
The thiazolyl-peptide antibiotic GE2270A, an inhibitor of the elongation factor Tu from Escherichia coli (EcEF-Tu), was used to… 
Review
2002
Review
2002
Inhibitory mechanisms of antibiotics targeting elongation factor Tu.
Since the pioneering discovery of the inhibitory effects of kirromycin on bacterial elongation factor Tu (EF-Tu) more than 25… 
2000
2000
GE2270A-resistant mutations in elongation factor Tu allow productive aminoacyl-tRNA binding to EF-Tu.GTP.GE2270A complexes.
The antibiotic GE2270A prevents stable complex formation between elongation factor Tu (EF-Tu) and aminoacyl-tRNA (aatRNA). In… 
1997
1997
Antimicrobial activities of chemically modified thiazolyl peptide antibiotic MDL 62,879 (GE2270A).
MDL 62,879 (GE2270A) 1 is a new inhibitor of elongation factor-Tu (EF-Tu) and belongs to the class of thiazolyl peptide… 
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