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GDC 0980

Known as: Dual PI3 Kinase/mTOR Inhibitor GDC-0980, GDC-0980, GDC0980 
An orally available agent targeting phosphatidylinositol 3 kinase (PI3K) and mammalian target of rapamycin (mTOR) kinase in the PI3K/mTOR signaling… Expand
National Institutes of Health

Papers overview

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2016
2016
PURPOSE This first-in-human phase I trial assessed the safety, tolerability, and preliminary antitumor activity of apitolisib… Expand
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2016
2016
BACKGROUND The current single-arm, open-label trial was designed to evaluate the activity of apitolisib (GDC-0980), a dual… Expand
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2016
2016
PURPOSE To the best of our knowledge, this study is the first to compare dual inhibition of PI3K/mammalian target of rapamycin… Expand
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Highly Cited
2014
Highly Cited
2014
IntroductionTriple negative breast cancer (TNBC) is a heterogeneous collection of biologically diverse cancers, which contributes… Expand
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Highly Cited
2011
Highly Cited
2011
The discovery of 2 (GDC-0980), a class I PI3K and mTOR kinase inhibitor for oncology indications, is described. mTOR inhibition… Expand
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Highly Cited
2011
Highly Cited
2011
Alterations of the phosphoinositide-3 kinase (PI3K)/Akt signaling pathway occur broadly in cancer via multiple mechanisms… Expand
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2011
2011
3020 Background: The PI3K-AKT-mTOR signaling pathway is deregulated in a wide variety of cancers. GDC-0980 is a potent, selective… Expand
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2004
2004
Early postoperative evaluation was prospectively performed in 35 gastric cancer patients after pylorus-preserving gastrectomy… Expand
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Highly Cited
1999
Highly Cited
1999
OBJECTIVE To evaluate whether the objectives of surgical treatment, i.e., prevention of aneurysmal rebleeding, relief of… Expand
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1990
1990
The discrimination mechanism between tRNA(Ser) and tRNA(Tyr) was studied using various in vitro transcripts of E. coli tRNATyr… Expand
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