GDC-0068

 

Topic mentions per year

Topic mentions per year

2011-2017
02420112017

Papers overview

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2017
2017
Activation of AKT signaling by PTEN loss or PIK3CA mutations occurs frequently in human cancers, but targeting AKT has been… (More)
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2016
2016
UNLABELLED Inhibitors of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway… (More)
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2015
2015
Loeys-Dietz syndrome (LDS) is an autosomal dominant genetic connective tissue disorder, and most of LDS patients will develop… (More)
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2014
2014
Both abundant epidermal growth factor receptor (EGFR or ErbB1) and high activity of the phosphatidylinositol 3-kinase (PI3K)-Akt… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE We describe the preclinical pharmacology and antitumor activity of GDC-0068, a novel highly selective ATP-competitive pan… (More)
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2013
2013
PURPOSE The oncogenic PI3K/Akt/mTOR pathway is an attractive therapeutic target in cancer. However, it is unknown whether the… (More)
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2013
2013
Purpose: The oncogenic PI3K/Akt/mTOR pathway is an attractive therapeutic target in cancer. However, it is unknown whether the… (More)
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2013
2013
Purpose:We describe the preclinical pharmacology and antitumor activity of GDC-0068, a novel highly selective ATP-competitive pan… (More)
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2012
2012
The discovery and optimization of a series of 6,7-dihydro-5H-cyclopenta[d]pyrimidine compounds that are ATP-competitive… (More)
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2011
2011
3022 Background: GDC-0068 is a highly selective ATP-competitive small molecule that inhibits all three isoforms of Akt with IC50… (More)
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