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GDC-0068

 
National Institutes of Health

Papers overview

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2019
2019
BACKGROUND Activating mutations in the PI3K/AKT/mTOR-pathway occur in 43-70% of breast cancer brain metastasis patients. To date… Expand
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Highly Cited
2017
Highly Cited
2017
Activation of AKT signaling by PTEN loss or PIK3CA mutations occurs frequently in human cancers, but targeting AKT has been… Expand
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2016
2016
Inhibitors of the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway hold… Expand
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2016
2016
5017Background: mCRPC commonly has hyperactivated PI3K/Akt signaling, usually via PTEN loss; androgen receptor (AR) blockade… Expand
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Highly Cited
2014
Highly Cited
2014
Predictions regarding drug resistance mechanisms and treatment strategies in triple-negative breast cancer are confirmed in… Expand
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Highly Cited
2013
Highly Cited
2013
Purpose: We describe the preclinical pharmacology and antitumor activity of GDC-0068, a novel highly selective ATP-competitive… Expand
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Highly Cited
2013
Highly Cited
2013
Purpose: The oncogenic PI3K/Akt/mTOR pathway is an attractive therapeutic target in cancer. However, it is unknown whether the… Expand
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Highly Cited
2012
Highly Cited
2012
The discovery and optimization of a series of 6,7-dihydro-5H-cyclopenta[d]pyrimidine compounds that are ATP-competitive… Expand
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2011
2011
3022 Background: GDC-0068 is a highly selective ATP-competitive small molecule that inhibits all three isoforms of Akt with IC50… Expand
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2011
2011
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Akt is one of the most frequently activated protein… Expand
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