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GC1008
Known as:
Anti-TGF-Beta Monoclonal Antibody GC1008
, Human Anti-TGF-Beta Monoclonal Antibody GC1008
, Immunoglobulin G4, anti-(transforming growth factor beta) (human monoclonal GC-1008 heavy chain), disulfide with human monoclonal GC-1008 light chain, Dimer
National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
fresolimumab
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
TGF-β Antibody Uptake in Recurrent High-Grade Glioma Imaged with 89Zr-Fresolimumab PET
M. W. den Hollander
,
F. Bensch
,
+11 authors
A. Walenkamp
Journal of Nuclear Medicine
2015
Corpus ID: 30212657
Transforming growth factor–β (TGF-β) signaling is involved in glioma development. The monoclonal antibody fresolimumab (GC1008…
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2014
2014
Anti-transforming growth factor-β therapy in patients with myelofibrosis
J. Mascarenhas
,
Timmy Li
,
+4 authors
R. Hoffman
Leukemia and Lymphoma
2014
Corpus ID: 588779
Bone marrow fi brosis (BMF), in the myeloproliferative neoplasm (MPN) myelofi brosis (MF), is the result of a complex and yet not…
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2014
2014
Structures of a pan‐specific antagonist antibody complexed to different isoforms of TGFβ reveal structural plasticity of antibody–antigen interactions
A. Moulin
,
M. Mathieu
,
+16 authors
R. Wei
Protein Science
2014
Corpus ID: 12528458
Various important biological pathways are modulated by TGFβ isoforms; as such they are potential targets for therapeutic…
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Highly Cited
2013
Highly Cited
2013
Immunological effects of the TGFβ-blocking antibody GC1008 in malignant pleural mesothelioma patients
J. Stevenson
,
H. Kindler
,
+11 authors
S. Albelda
Oncoimmunology
2013
Corpus ID: 12481314
We evaluated a neutralizing anti-TGFβ antibody (GC1008) in cancer patients with malignant pleura mesothelioma (MPM). The goal of…
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2013
2013
(89)zr-GC1008 PET imaging and GC1008 treatment of recurrent glioma patients.
M. D. Hollander
,
F. Bensch
,
+8 authors
A. Walenkamp
2013
Corpus ID: 59318865
2050 Background: Transforming growth factor-β (TGF-β) signaling is involved in glioma development. GC1008 is a monoclonal…
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2012
2012
Phase II trial of anti-transforming growth factor-beta (TGFß) monoclonal antibody GC1008 in relapsed malignant pleural mesothelioma (MPM).
J. Stevenson
,
H. Kindler
,
+8 authors
S. Albelda
2012
Corpus ID: 78476975
7077 Background: TGFβ is a pleiotropic cytokine overexpressed by MPM. Based on preclinical data documenting a key role for TGF…
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