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GABA Uptake Inhibitors

Known as: Reuptake Inhibitors, GABA, Gamma Aminobutyric Acid Plasma Membrane Transport Inhibitors, Uptake Inhibitors, Gamma-Aminobutyric Acid 
Compounds that suppress or block the plasma membrane transport of GAMMA-AMINOBUTYRIC ACID by GABA PLASMA MEMBRANE TRANSPORT PROTEINS.
National Institutes of Health

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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.
β-Amino acids sharing a lipophilic diaromatic side chain were synthesized and characterized pharmacologically on mouse GABA… 
Review
2000
Review
2000
GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.
In the mid seventies a drug design programme using the Amanita muscaria constituent muscimol (7) as a lead structure, led to the… 
1999
1999
Synthesis of novel GABA uptake inhibitors. 4. Bioisosteric transformation and successive optimization of known GABA uptake inhibitors leading to a series of potent anticonvulsant drug candidates.
By bioisosteric transformations and successive optimization of known GABA uptake inhibitors, several series of novel GABA uptake… 
Highly Cited
1999
Highly Cited
1999
Synthesis of novel GABA uptake inhibitors. 3. Diaryloxime and diarylvinyl ether derivatives of nipecotic acid and guvacine as anticonvulsant agents.
(3R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid 1 (tiagabine, Gabitril) is a potent and selective… 
Highly Cited
1996
Highly Cited
1996
Nitric oxide-evoked [3H] gamma-aminobutyric acid release is mediated by two distinct release mechanisms.
Highly Cited
1994
Highly Cited
1994
Design, synthesis and evaluation of substituted triarylnipecotic acid derivatives as GABA uptake inhibitors: identification of a ligand with moderate affinity and selectivity for the cloned human…
gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the mammalian central nervous system. Molecular… 
Highly Cited
1990
Highly Cited
1990
(R)‐N‐[4,4‐Bis(3‐Methyl‐2‐Thienyl)but‐3‐en‐1‐yl]Nipecotic Acid Binds with High Affinity to the Brain γ‐Aminobutyric Acid Uptake Carrier
(R)‐N‐[4,4‐Bis(3‐methyl‐2‐thienyl)but‐3‐en‐l‐yl]nipecotic acid (NO 328) has previously been shown to be a potent anticonvulsant… 
Highly Cited
1980
Highly Cited
1980
Identification of GABA neurons in rat cortical cultures by GABA uptake autoradiography
Highly Cited
1978
Highly Cited
1978
STRUCTURE‐ACTIVITY STUDIES ON THE INHIBITION OF GABA BINDING TO RAT BRAIN MEMBRANES BY MUSCIMOL AND RELATED COMPOUNDS
Abstract— A series of compounds structurally related to muscimol (5‐aminomethyl‐3‐isoxazolol) was tested as inhibitors of the… 
Highly Cited
1978
Highly Cited
1978
Inhibition of [3H]dopamine accumulation in rat striatal synaptosomes by psychotropic drugs.
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