G007-LK

 
National Institutes of Health

Papers overview

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2018
2018
Tankyrase is a poly (ADP-ribose) polymerase that leads to ubiquitination and degradation of target proteins. Since tankyrase… Expand
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Review
2017
Review
2017
Cancer stem cells (CSCs), which have the potential for self-renewal, differentiation and de-differentiation, undergo epigenetic… Expand
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2017
2017
BackgroundThe WNT pathway regulates intestinal stem cells and is frequently disrupted in intestinal adenomas. The pathway… Expand
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2017
2017
Gastrointestinal stromal tumor (GIST) is the most common type of sarcoma and usually harbors either a KIT or PDGFRA mutation… Expand
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2017
2017
Activation of Wnt/β-catenin signaling is essential for colorectal carcinogenesis. Tankyrase, a member of the poly(ADP-ribose… Expand
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2017
2017
Previous data indicate that Tankyrase inhibitors exert anti-growth functions in many cancer cell lines due to their ability to… Expand
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2017
2017
Inhibition of the tankyrase enzymes (TNKS1 and TNKS2) has recently been shown to induce highly dynamic assemblies of β-catenin… Expand
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2015
2015
UNLABELLED Tankyrase (TNKS) enzymes, due to their poly(ADP-ribose) polymerase activity, have emerged as potential targets in… Expand
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2013
2013
Tankyrases 1 and 2 (TNKS1/2) are promising pharmacological biotargets with possible applications for the development of novel… Expand
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Highly Cited
2013
Highly Cited
2013
Most colorectal cancers (CRC) are initiated by mutations of APC, leading to increased β-catenin-mediated signaling. However… Expand
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