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Fusion Toxin

A receptor-targeted complex comprised of a truncated toxin fused to a hormone, growth factor, or immunologic agent (i.e. antibody) that binds to the… Expand
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
Purpose: Designed ankyrin repeat proteins (DARPins) hold great promise as a new class of binding molecules to overcome the… Expand
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2007
2007
B lymphocyte stimulator (BLyS) is crucial for B-cell survival, and the biological effects of BLyS are mediated by three cell… Expand
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Review
2001
Review
2001
  • F. Foss
  • Annals of the New York Academy of Sciences
  • 2001
  • Corpus ID: 23040651
Abstract: The interleukin (IL)‐2 receptor has proved an attractive target for T cell‐directed therapies. Agents including… Expand
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Highly Cited
1998
Highly Cited
1998
BACKGROUND DAB389IL-2 is a novel fusion toxin that retargets the cytotoxic A-chain of diphtheria toxin to interleukin-2 (IL-2… Expand
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Highly Cited
1996
Highly Cited
1996
The high-affinity interleukin 2 (IL-2) receptor is a heterotrimer consisting of alpha, beta, and gamma subunits. We examined the… Expand
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Highly Cited
1994
Highly Cited
1994
Background. DAB486IL‐2 is a recombinant fusion toxin in which the native diphtheria toxin‐receptor binding‐domain has been… Expand
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Highly Cited
1993
Highly Cited
1993
DAB486IL-2, a recombinant fusion toxin in which the native receptor binding domain of diphtheria toxin has been replaced with… Expand
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1993
1993
OBJECTIVE To evaluate the safety and antiarthritic effects of DAB486IL-2. This agent is a fusion toxin and the product of a… Expand
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Highly Cited
1992
Highly Cited
1992
: DAB486IL-2 is a recombinant fusion toxin in which the native receptor binding domain of diphtheria toxin has been replaced with… Expand
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Highly Cited
1990
Highly Cited
1990
We have used site-directed mutagenesis to examine the role played by Arg191, Arg193, and Arg194 of the fusion toxin DAB486-IL-2… Expand
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