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Purpose: Designed ankyrin repeat proteins (DARPins) hold great promise as a new class of binding molecules to overcome the… Expand B lymphocyte stimulator (BLyS) is crucial for B-cell survival, and the biological effects of BLyS are mediated by three cell… Expand Abstract: The interleukin (IL)‐2 receptor has proved an attractive target for T cell‐directed therapies. Agents including… Expand BACKGROUND
DAB389IL-2 is a novel fusion toxin that retargets the cytotoxic A-chain of diphtheria toxin to interleukin-2 (IL-2… Expand The high-affinity interleukin 2 (IL-2) receptor is a heterotrimer consisting of alpha, beta, and gamma subunits. We examined the… Expand Background. DAB486IL‐2 is a recombinant fusion toxin in which the native diphtheria toxin‐receptor binding‐domain has been… Expand DAB486IL-2, a recombinant fusion toxin in which the native receptor binding domain of diphtheria toxin has been replaced with… Expand OBJECTIVE
To evaluate the safety and antiarthritic effects of DAB486IL-2. This agent is a fusion toxin and the product of a… Expand DAB486IL-2 is a recombinant fusion toxin in which the native receptor binding domain of diphtheria toxin has been replaced with… Expand We have used site-directed mutagenesis to examine the role played by Arg191, Arg193, and Arg194 of the fusion toxin DAB486-IL-2… Expand