Fusion Toxin

A receptor-targeted complex comprised of a truncated toxin fused to a hormone, growth factor, or immunologic agent (i.e. antibody) that binds to the… (More)
National Institutes of Health

Papers overview

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2017
2017
Ontak® is a FDA-approved diphtheria toxin-based recombinant fusion toxin for treatment of human CD25+ cutaneous T cell lymphoma… (More)
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2011
2011
PURPOSE Designed ankyrin repeat proteins (DARPins) hold great promise as a new class of binding molecules to overcome the… (More)
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2007
2007
B lymphocyte stimulator (BLyS) is crucial for B-cell survival, and the biological effects of BLyS are mediated by three cell… (More)
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2004
2004
The fusion toxin DT388IL3 composed of the catalytic and translocation domains of diphtheria toxin (DT388) linked to interleukin-3… (More)
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Review
2001
Review
2001
The interleukin (IL)-2 receptor has proved an attractive target for T cell-directed therapies. Agents including monoclonal… (More)
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1998
1998
BACKGROUND DAB389IL-2 is a novel fusion toxin that retargets the cytotoxic A-chain of diphtheria toxin to interleukin-2 (IL-2… (More)
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1996
1996
Myeloid leukemias can express interleukin-3 receptors (IL-3R). Therefore, as an antileukemia drug, a fusion immunotoxin was… (More)
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1993
1993
DAB486IL-2, a recombinant fusion toxin in which the native receptor binding domain of diphtheria toxin has been replaced with… (More)
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1992
1992
DAB486IL-2 is a recombinant fusion toxin in which the native receptor binding domain of diphtheria toxin has been replaced with… (More)
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1992
1992
Insulin-dependent diabetes mellitus (IDDM) is strikingly similar in the non-obese diabetic (NOD) mouse and humans. In IDDM, the… (More)
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