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Fragments

Known as: Fragment 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
05101519912017

Papers overview

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2016
2016
Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
3-Phosphoglycerate dehydrogenase (PHGDH) has recently been identified as an attractive target in cancer therapy as it links… (More)
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2016
2016
Fragment-Based Whole Cell Screen Delivers Hits against M. tuberculosis and Non-tuberculous Mycobacteria
Reactive multi-target 'fragment drugs' represent critical components of current tuberculosis regimens. These compounds, such as… (More)
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2015
2015
Influence of fragment size and postoperative joint congruency on long-term outcome of posterior malleolar fractures.
BACKGROUND One of the factors contributing to long-term outcome of posterior malleolar fractures is the development of… (More)
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2015
2015
Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies.
A first step in fragment-based drug discovery (FBDD) often entails a fragment-based screen (FBS) to identify fragment "hits… (More)
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2014
2014
A highly immunogenic fragment derived from Zaire Ebola virus glycoprotein elicits effective neutralizing antibody.
In order to produce polyvalent vaccines based on single rVSV vector, we investigated the immunogenicity, antibody neutralizing… (More)
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2014
2014
Pharmacokinetics and PET imaging properties of two recombinant anti-PSMA antibody fragments in comparison to their parental antibody.
BACKGROUND Radioimmunoimaging with disease-specific tracers can be advantageous compared to that with nonspecific tracers for the… (More)
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2014
2014
A simple fragment of cyclic acyldepsipeptides is necessary and sufficient for ClpP activation and antibacterial activity.
The development of new antibacterial agents, particularly those with unique biological targets, is essential to keep pace with… (More)
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2013
2013
Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors.
The identification of a novel series of small molecule BET inhibitors is described. Using crystallographic binding modes of an… (More)
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2011
2011
Rainbow trout surviving infections of viral haemorrhagic septicemia virus (VHSV) show lasting antibodies to recombinant G protein fragments.
Rainbow trout antibodies (Abs) binding to recombinant fragments (frgs) derived from the protein G of the viral haemorrhagic… (More)
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2009
2009
Interaction of diphtheria toxin (fragment A) with actin.
It was shown by gel filtration and viscosity measurements that N-terminal fragment (FA) of diphtheria toxin (DT) can interact… (More)
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