FluoZin-3

For more than 50 years, it has been known that zinc deficiency compromises immune function. During this time, knowledge about the… Expand

The toxicological effects of zinc oxide nanoparticles (ZnO-NPs) are attracting increasing concern as the field of nanotechnology… Expand

Zinc signals, i.e. a change of the intracellular concentration of free zinc ions in response to receptor stimulation, are… Expand

Lysosomal membrane permeabilization (LMP) is implicated in cancer cell death. However, its role and mechanism of action in… Expand

There has been some dispute in the literature as to the sensitivity of the zinc indicator FluoZin-3 to calcium, with suggestions… Expand

Each of the seven Zn(II) ions in the Zn(3)S(9) and Zn(4)S(11) clusters of human metallothionein is in a tetrathiolate… Expand

Elevation of intracellular free zinc ([Zn2+]i) probably contributes to cell death in injury paradigms involving calcium… Expand

Exocytosis of synaptic vesicle contents defines the quantal nature of neurotransmitter release. Here we developed a technique to… Expand

Zinc is an effector of insulin/IGF-1 signaling and has insulinomimetic effects, the molecular basis of which is not understood… Expand

A novel Zn2+-selective visible wavelength fluoroionophore (FluoZin-3, 9) was synthesized. The chelating portion of the molecule… Expand