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First-Line Therapy

Known as: primary therapy, First Line Therapy, First Line Treatment 
Initial treatment used to reduce a cancer. First-line therapy is followed by other treatments, such as chemotherapy, radiation therapy, and hormone… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Breast Cancer, Version 4.2017, NCCN Clinical Practice Guidelines in Oncology.
Ductal carcinoma in situ (DCIS) of the breast represents a heterogeneous group of neoplastic lesions in the breast ducts. The… 
Highly Cited
2009
Highly Cited
2009
Long‐term monitoring shows hepatitis B virus resistance to entecavir in nucleoside‐naïve patients is rare through 5 years of therapy
Patients with chronic hepatitis B virus (HBV) infection who develop antiviral resistance lose benefits of therapy and may be… 
Highly Cited
2005
Highly Cited
2005
Colorectal cancer surveillance: 2005 update of an American Society of Clinical Oncology practice guideline.
PURPOSE To update the 2000 American Society of Clinical Oncology guideline on colorectal cancer surveillance. RECOMMENDATIONS… 
Review
2005
Review
2005
The role of transjugular intrahepatic portosystemic shunt in the management of portal hypertension
The recommendations in this article provide a datasupported approach. They are based on the following: (1) a formal review and… 
Highly Cited
2005
Highly Cited
2005
Long-term outcomes among localized prostate cancer survivors: health-related quality-of-life changes after radical prostatectomy, external radiation, and brachytherapy.
PURPOSE We sought to elucidate long-term changes in health-related quality-of-life (HRQOL) outcomes by prospectively re… 
Review
2004
Review
2004
Ductal carcinoma in situ, complexities and challenges.
The incidence of ductal carcinoma in situ (DCIS), a noninvasive form of breast cancer, has increased markedly in recent decades… 
Highly Cited
2000
Highly Cited
2000
Role of breast reconstructive surgery in physical and emotional outcomes among breast cancer survivors.
BACKGROUND Tissue-sparing approaches to primary treatment and reconstructive options provide improved cosmetic outcomes for women… 
Highly Cited
1996
Highly Cited
1996
Annual hazard rates of recurrence for breast cancer after primary therapy.
PURPOSE To determine if the long-term increase of recurrence for breast cancer is stable or slowly decreasing, or if it ever… 
Highly Cited
1995
Highly Cited
1995
Prolonged Survival in Chronic Myelogenous Leukemia after Cytogenetic Response to Interferon- Therapy
Table. SI Units and Abbreviation Chronic myelogenous leukemia is characterized by the presence of the Philadelphia chromosome (Ph… 
Highly Cited
1975
Highly Cited
1975
Surgical resection of tumor bulk in the primary treatment of ovarian carcinoma.
The effect of tumor bulk resection on survival was studied in 102 patients with stages II and III ovarian cancer. A multiple… 
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