Fibroblast Growth Factor 21, human

Known as: FGF-21, FGF21, Fibroblast Growth Factor 21 
Fibroblast growth factor 21 (209 aa, ~22 kDa) is encoded by the human FGF21 gene. This protein may play a role in glucose metabolism in adipocytes.
National Institutes of Health

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Angiogenic ProcessCell Differentiation processCell Proliferation Regulatory ProcessExtracellular Space
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fibroblast growth factor 21

Papers overview

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2014
2014
Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue.
OBJECTIVE In rodents, brown (BAT) and white (WAT) adipose tissues are targets and expression sites for fibroblast growth factor… (More)
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Highly Cited
2012
Highly Cited
2012
The starvation hormone, fibroblast growth factor-21, extends lifespan in mice
Fibroblast growth factor-21 (FGF21) is a hormone secreted by the liver during fasting that elicits diverse aspects of the… (More)
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2012
2012
Fibroblast Growth Factor 21: A Novel Metabolic Regulator
Corresponding author: Nan Hee Kim Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University… (More)
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Highly Cited
2011
Highly Cited
2011
Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes.
Fibroblast growth factor (FGF) 21 and growth hormone (GH) are metabolic hormones that play important roles in regulating glucose… (More)
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Highly Cited
2009
Highly Cited
2009
Circulating Fibroblast Growth Factor-21 Is Elevated in Impaired Glucose Tolerance and Type 2 Diabetes and Correlates With Muscle and Hepatic Insulin Resistance
OBJECTIVE Fibroblast growth factor (FGF)-21 is highly expressed in the liver and regulates hepatic glucose production and lipid… (More)
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Highly Cited
2009
Highly Cited
2009
Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity.
OBJECTIVE Fibroblast growth factor-21 (FGF21) is a novel endocrine and paracrine regulator of metabolic homeostasis. The aim of… (More)
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Highly Cited
2009
Highly Cited
2009
Fibroblast Growth Factor-21 Is Induced in Human Skeletal Muscles by Hyperinsulinemia
OBJECTIVE Fibroblast growth factor-21 (FGF-21) is a potent metabolic regulator, which in animal models has been shown to improve… (More)
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Highly Cited
2009
Highly Cited
2009
Free Fatty Acids Link Metabolism and Regulation of the Insulin-Sensitizing Fibroblast Growth Factor-21
OBJECTIVE Fibroblast growth factor (FGF)-21 improves insulin sensitivity and lipid metabolism in obese or diabetic animal models… (More)
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Highly Cited
2009
Highly Cited
2009
Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma-glutamyltransferase but not insulin sensitivity in Chinese subjects.
OBJECTIVE Fibroblast growth factor (FGF) 21, a hormone primarily secreted by liver, has recently been shown to have beneficial… (More)
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Highly Cited
2007
Highly Cited
2007
Circulating FGF-21 levels in normal subjects and in newly diagnose patients with Type 2 diabetes mellitus.
Fibroplast growth factor (FGF-21) is a recently discovered metabolic regulator. Its pathophysiologic role in humans remains… (More)
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