Fenamates, antiinflammatory and antirheumatic drugs

Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase-1 (COX-1) and COX-2 enzymes. The NLRP3 inflammasome is a… (More)

BACKGROUND AND PURPOSE Fenamates are N-phenyl-substituted anthranilic acid derivatives clinically used as non-steroid anti… (More)

Research into Ca2+-activated Cl- channels is hampered by the inability to decipher their molecular identity and the fact that all… (More)

CLC-K Cl(-) channels are selectively expressed in kidney and ear, where they are pivotal for salt homeostasis, and loss-of… (More)

A swelling-activated, background K+ current in the corneal epithelium is characteristically activated by fenamates and inhibited… (More)

The effect of fenamates on gap junctional intercellular communication was investigated in monolayers of normal rat kidney (NRK… (More)

Genetic and physiological studies have established a link between potassium channel dysfunction and a number of neurological and… (More)

The Kv4.3 K+ channel is thought to underlie the Ca(2+)-insensitive transient outward current (I(to1)) in ventricular myocytes of… (More)

N-Arylanthranilic acids, known generically as the fenamates, are nonsteroidal antiinflammatory drugs (NSAIDs) that block the… (More)

1. A perforated patch clamp technique was used to study an outward potassium current in freshly dissociated circular smooth… (More)