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Factor VIIa

Known as: VIIa, Coagulation Factor, Coagulation factor VIIa, Factor VIIa [Chemical/Ingredient] 
Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagulation.
National Institutes of Health

Related topics

Related topics

17 relations
CoagulantsProcess of secretionagonistsantagonists & inhibitors

Narrower (7)

MC710Novosevendes(1-38) factor VIIaglycoPEGylated factor VIIa

Broader (1)

factor VII

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Safety of recombinant activated factor VII in randomized clinical trials.
BACKGROUND The use of recombinant activated factor VII (rFVIIa) on an off-label basis to treat life-threatening bleeding has been… 
Highly Cited
2009
Highly Cited
2009
Safety and Efficacy of Recombinant Activated Factor VII: A Randomized Placebo-Controlled Trial in the Setting of Bleeding After Cardiac Surgery
Background— Blood loss is a common complication of cardiac surgery. Evidence suggests that recombinant activated factor VII… 
Highly Cited
2008
Highly Cited
2008
Neutrophil activation by the tissue factor/Factor VIIa/PAR2 axis mediates fetal death in a mouse model of antiphospholipid syndrome.
Women with antiphospholipid syndrome (APS), a condition characterized by the presence of antiphospholipid antibodies (aPL), often… 
Highly Cited
2005
Highly Cited
2005
Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials.
BACKGROUND Uncontrolled bleeding is a leading cause of death in trauma. Two randomized, placebo-controlled, double-blind trials… 
Review
2004
Review
2004
Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitors
Summary.  Recombinant factor (rF)VIIa has been available to clinicians since 1996 and has an excellent safety record after almost… 
Highly Cited
2003
Highly Cited
2003
The effect of temperature and pH on the activity of factor VIIa: implications for the efficacy of high-dose factor VIIa in hypothermic and acidotic patients.
BACKGROUND Recombinant coagulation factor VIIa (FVIIa) is approved for treating hemophiliacs with inhibitors. High-dose FVIIa has… 
Highly Cited
2001
Highly Cited
2001
REDUCED TRANSFUSION REQUIREMENTS BY RECOMBINANT FACTOR VIIa IN ORTHOTOPIC LIVER TRANSPLANTATION: A Pilot Study
Background. Large transfusion requirements, i.e., excessive blood loss, during orthotopic liver transplantation (OLT) are… 
Highly Cited
1996
Highly Cited
1996
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor
Blood coagulation is initiated when tissue factor binds to coagulation factor Vila to give an enzymatically active complex which… 
Highly Cited
1995
Highly Cited
1995
Extrinsic-pathway activation in cancer with high factor Vlla and tissue factor
Highly Cited
1988
Highly Cited
1988
Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells.
Blood coagulation factor VII is a vitamin K dependent glycoprotein which in its activated form, factor VIIa, participates in the… 
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