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FXR1 gene

Known as: FRAGILE X-RELATED PROTEIN 1, FXR1, FMR1 autosomal homolog 1 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
FMR1 targets distinct mRNA sequence elements to regulate protein expression
Fragile X syndrome (FXS) is a multi-organ disease that leads to mental retardation, macro-orchidism in males and premature… 
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Highly Cited
2009
Highly Cited
2009
The FXG: A Presynaptic Fragile X Granule Expressed in a Subset of Developing Brain Circuits
The loss of Fragile X mental retardation protein (FMRP) causes Fragile X syndrome, the most common inherited mental retardation… 
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Highly Cited
2004
Highly Cited
2004
Fxr1 knockout mice show a striated muscle phenotype: implications for Fxr1p function in vivo.
FXR1 is one of the two known homologues of FMR1. FXR1 shares a high degree of sequence homology with FMR1 and also encodes two KH… 
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Highly Cited
2002
Highly Cited
2002
Knockout mouse model for Fxr2: a model for mental retardation.
Fragile X syndrome is a common form of mental retardation caused by the absence of the FMR1 protein, FMRP. Fmr1 knockout mice… 
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Highly Cited
2001
Highly Cited
2001
A highly conserved protein family interacting with the fragile X mental retardation protein (FMRP) and displaying selective interactions with FMRP-related proteins FXR1P and FXR2P
The absence of the fragile X mental retardation protein (FMRP), encoded by the FMR1 gene, is responsible for pathologic… 
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Highly Cited
1999
Highly Cited
1999
Isolation of an FMRP-Associated Messenger Ribonucleoprotein Particle and Identification of Nucleolin and the Fragile X-Related Proteins as Components of the Complex
ABSTRACT The loss of FMR1 expression due to trinucleotide repeat expansion leads to fragile X syndrome, a cause of mental… 
Highly Cited
1999
Highly Cited
1999
Different targets for the fragile X-related proteins revealed by their distinct nuclear localizations.
Fragile X syndrome is caused by the absence of the fragile X mental retardation protein (FMRP). FMRP and its structural… 
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Highly Cited
1997
Highly Cited
1997
Differential expression of FMR1, FXR1 and FXR2 proteins in human brain and testis.
Lack of expression of the fragile X mental retardation protein (FMRP) results in mental retardation and macroorchidism, seen as… 
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Highly Cited
1995
Highly Cited
1995
The fragile X mental retardation syndrome protein interacts with novel homologs FXR1 and FXR2.
Fragile X Mental Retardation Syndrome is the most common form of hereditary mental retardation, and is caused by defects in the… 
Highly Cited
1995
Highly Cited
1995
FXR1, an autosomal homolog of the fragile X mental retardation gene.
Fragile X mental retardation syndrome, the most common cause of hereditary mental retardation, is directly associated with the… 
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