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FR 900098

Known as: FR-900098 
National Institutes of Health

Papers overview

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2019
2019
Deciphering structure, function and mechanism of Plasmodium IspD homologs from their evolutionary imprints
Malaria is a life-threatening mosquito-borne blood disease caused by infection with Plasmodium parasites. Anti-malarial drug… 
2016
2016
FR-900098, an antimalarial development candidate that inhibits the non-mevalonate isoprenoid biosynthesis pathway, shows no evidence of acute toxicity and genotoxicity
ABSTRACT FR-900098 is an inhibitor of 1-deoxy-d-xylulose-5-phosphate (DXP) reductoisomerase, the second enzyme in the non… 
2016
2016
Potentiation of the Fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida.
A library of 33 compounds was screened for potentiation of the antibiotic FR 900098 against the Francisella tularensis surrogate… 
2015
2015
Structure-guided design and biosynthesis of a novel FR-900098 analogue as a potent Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (Dxr) inhibitor.
We report here the enzymatic biosynthesis of FR-900098 analogues and establish an in vivo platform for the biosynthesis of an N… 
2012
2012
Microbial synthesis of antimalarial compound FR-900098: pathway characterization and engineering
2011
2011
Phosphonate Biosynthetic Enzyme FrbF Structure and Mechanism of the-Acetyltransferase Fold in the N New Protein Structure and Folding :
2009
2009
Development of HPLC/UV and HPLC/MS analytical methods for FR-900098 : a novel antimalarial compound experimental pharmacokinetic studies on rat and micro-pig
FR-900098, un derive proche de la fosmydomicine, inhibite la croissance du parasite Plasmodium falciparum de maniere deux fois… 
2008
2008
Directed evolution of phosphite dehydrogenase and engineered biosynthesis of FR-900098
Highly Cited
1982
Highly Cited
1982
Studies on phosphonic acid antibiotics. IV. Synthesis and antibacterial activity of analogs of 3-(N-acetyl-N-hydroxyamino)-propylphosphonic acid (FR-900098).
The synthesis of analogs of 3-(N-acetyl-N-hydroxyamino) propylphosphonic acid (FR-900098, Ia) and an analysis of their structure… 
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