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Several mechanistically unrelated enzymes utilize the binding energy of their substrate’s nonreacting phosphoryl group to… Expand The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway leads to the synthesis of isopentenyl diphosphate in plastids. It is a… Expand Natural product biosynthesis has proven a fertile ground for the discovery of novel chemistry. Herein we review the progress made… Expand A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize the essential isoprenoid precursor… Expand FR-900098 is a potent chemotherapeutic agent for the treatment of malaria. Here we report the heterologous production of this… Expand Two Pseudomonas aeruginosa genes encoding the enzymes 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase… Expand A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective… Expand The synthesis of analogs of 3-(N-acetyl-N-hydroxyamino) propylphosphonic acid (FR-900098, Ia) and an analysis of their structure… Expand Three phosphonic acid antibiotics were found to be produced in the fermentation broths of Streptomyces. FR-31564 and FR-32863… Expand A strain of Streptomyces, isolated from a soil sample and identified as Streptomyces rubellomurinus sp. nov., has been found to… Expand