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FR 900098

Known as: FR-900098 
National Institutes of Health

Papers overview

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2015
2015
Several mechanistically unrelated enzymes utilize the binding energy of their substrate’s nonreacting phosphoryl group to… Expand
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2014
2014
The 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway leads to the synthesis of isopentenyl diphosphate in plastids. It is a… Expand
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Review
2013
Review
2013
Natural product biosynthesis has proven a fertile ground for the discovery of novel chemistry. Herein we review the progress made… Expand
2012
2012
A number of pathogens, including the causative agents of tuberculosis and malaria, synthesize the essential isoprenoid precursor… Expand
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2010
2010
FR-900098 is a potent chemotherapeutic agent for the treatment of malaria. Here we report the heterologous production of this… Expand
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Highly Cited
2000
Highly Cited
2000
Two Pseudomonas aeruginosa genes encoding the enzymes 1-deoxy-D-xylulose 5-phosphate (DXP) synthase and DXP reductoisomerase… Expand
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Highly Cited
1999
Highly Cited
1999
A mevalonate-independent pathway of isoprenoid biosynthesis present in Plasmodium falciparum was shown to represent an effective… Expand
1982
1982
The synthesis of analogs of 3-(N-acetyl-N-hydroxyamino) propylphosphonic acid (FR-900098, Ia) and an analysis of their structure… Expand
Highly Cited
1980
Highly Cited
1980
Three phosphonic acid antibiotics were found to be produced in the fermentation broths of Streptomyces. FR-31564 and FR-32863… Expand
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1980
1980
A strain of Streptomyces, isolated from a soil sample and identified as Streptomyces rubellomurinus sp. nov., has been found to… Expand