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FLT3 wt Allele

Known as: FLT3, FLK2, STK1 
Human FLT3 wild-type allele is located within 13q12 and is approximately 97 kb in length. This allele, which encodes receptor-type tyrosine-protein… 
National Institutes of Health

Related topics

Related topics

12 relations
13q12Acute Myeloid Leukemia with FLT3/ITD MutationCell Proliferation Regulatory ProcessErythrocyte Differentiation Pathway

Broader (1)

FLT3 gene

Papers overview

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2016
2016
Impact of Age and Midostaurin-Dose on Response and Outcome in Acute Myeloid Leukemia with FLT3-ITD: Interim-Analyses of the AMLSG 16-10 Trial
Background: Internal tandem duplications (ITD) in the receptor tyrosine kinase FLT3 occur in roughly 25% of younger adult… 
2010
2010
SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control.
Activating mutations in the receptor tyrosine kinase FLT3 are frequently found in acute myelogenous leukemia patients and confer… 
2008
2008
Transformation by Oncogenic Mutants and Ligand-Dependent Activation of FLT3 Wild-type Requires the Tyrosine Residues 589 and 591
Purpose: Mutations in the receptor tyrosine kinase FLT3 are found in up to 30% of acute myelogenous leukemia patients and are… 
Highly Cited
2002
Highly Cited
2002
Internal tandem duplication of FLT3 in relapsed acute myeloid leukemia: a comparative analysis of bone marrow samples from 108 adult patients at diagnosis and relapse.
Analysis of internal tandem duplications of FLT3 (FLT3/ITD) was performed on bone marrow samples obtained at diagnosis and… 
Highly Cited
2002
Highly Cited
2002
Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia
Recently, an internal tandem duplication of the FLT3 gene (FLT3/ITD) was found in approximately 20% of adult acute myeloid… 
Highly Cited
2001
Highly Cited
2001
A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations.
Internal tandem duplication (ITD) mutations of the receptor tyrosine kinase FLT3 have been found in 20% to 30% of patients with… 
Highly Cited
2000
Highly Cited
2000
Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts
In the present study, we examined the underlying mechanism, which causes the constitutive tyrosine phosphorylation of signal… 
Highly Cited
2000
Highly Cited
2000
Constitutive activation of FLT3 in acute myeloid leukaemia and its consequences for growth of 32D cells
The receptor tyrosine kinase Flt3 is expressed on leukaemic blasts of most cases with acute myeloid leukaemia (AML). In order to… 
Highly Cited
1995
Highly Cited
1995
Multi-level effects of flt3 ligand on human hematopoiesis: expansion of putative stem cells and proliferation of granulomonocytic progenitors/monocytic precursors.
We have evaluated the effects of the flt3 receptor ligand (FL) on hematopoietic progenitors/stem cells (HPCs/HSCs) stringently… 
1995
1995
Localization of the human stem cell tyrosine kinase-1 gene (FLT3) to 13q12-->q13.
We have previously reported the cloning of stem cell tyrosine kinase-1 (STK-1, gene symbol FLT3), the human homolog of the mouse… 
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