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FLT3 wt Allele

Known as: FLT3, FLK2, STK1 
Human FLT3 wild-type allele is located within 13q12 and is approximately 97 kb in length. This allele, which encodes receptor-type tyrosine-protein… 
National Institutes of Health

Related topics

Related topics

12 relations
13q12Acute Myeloid Leukemia with FLT3/ITD MutationCell Proliferation Regulatory ProcessErythrocyte Differentiation Pathway

Broader (1)

FLT3 gene

Papers overview

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2019
2019
Role of CD135/CD117 on Prognosis and Overall Survival of Acute Myeloid Leukemia
Background: The key proliferative RTKs for AML include c-KIT receptor (CD117) and FLT-3 receptor (CD135). The aim of this study… 
2019
2019
Abstract 3841: Therapeutic targeting ofFLT3mutations in AML via menin-MLL1 and FLT3 inhibition
Acute myeloid leukemias (AML) that are driven by MLL1 (KMT2A)-fusion proteins (MLL-f) or NPM1 mutations (NPM1mut) are both… 
Review
2018
Review
2018
The clinical significance of FLT3 ITD mutation on the prognosis of adult acute promyelocytic leukemia
ABSTRACT Background and aims: To explore the relationship between FLT3 (encoding Fms related tyrosine kinase 3) internal tandem… 
2015
2015
Effect of vorinostat use on survival in patients with acute myeloid leukemia (AML) with FLT3 ITD mutations.
e18019 Background: Novel treatment strategies for patients with AML remain an unmet need. Treatment with vorinostat for three… 
2013
2013
Crenolanib for treating flt3 mutated proliferative disorders
2013
2013
Inhibiteurs de fak et flt3
L'invention concerne l'utilisation d'un compose de formule (I) : (formule (I)) dans la preparation d'un medicament permettant de… 
2008
2008
Transformation by Oncogenic Mutants and Ligand-Dependent Activation of FLT3 Wild-type Requires the Tyrosine Residues 589 and 591
Purpose: Mutations in the receptor tyrosine kinase FLT3 are found in up to 30% of acute myelogenous leukemia patients and are… 
Review
2005
Review
2005
[Mutations of the gene coding for the receptor tyrosine kinase FLT3 in acute myeloid leukemia. Significance as the disease-specific molecular marker for diagnosis, prognosis and innovative therapy…
1999
1999
Early progenitor cells from human mobilized peripheral blood express low levels of the flt3 receptor, but exhibit various biological responses to flt3‐L
The biological effects of flt3‐L, and the expression of its tyrosine kinase receptor (flt3, CD135) were investigated on the… 
1997
1997
G-CSF-mobilized peripheral blood progenitor cells: in vitro growth pattern and hematopoietic growth factor receptor profile.
The kinetics of colony formation by granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood progenitor cells… 
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