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FLT3 wt Allele
Known as:
FLT3
, FLK2
, STK1
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Human FLT3 wild-type allele is located within 13q12 and is approximately 97 kb in length. This allele, which encodes receptor-type tyrosine-protein…
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National Institutes of Health
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Related topics
Related topics
12 relations
13q12
Acute Myeloid Leukemia with FLT3/ITD Mutation
Cell Proliferation Regulatory Process
Erythrocyte Differentiation Pathway
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Broader (1)
FLT3 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Role of CD135/CD117 on Prognosis and Overall Survival of Acute Myeloid Leukemia
M. Raeisi
,
A. R. Nikhanfar
,
+4 authors
Z. Sanaat
Asian Pacific Journal of Cancer Prevention
2019
Corpus ID: 203438637
Background: The key proliferative RTKs for AML include c-KIT receptor (CD117) and FLT-3 receptor (CD135). The aim of this study…
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2019
2019
Abstract 3841: Therapeutic targeting ofFLT3mutations in AML via menin-MLL1 and FLT3 inhibition
Margarita M. Dzama
,
Martha C Taubert
,
+9 authors
M. Kühn
Experimental and Molecular Therapeutics
2019
Corpus ID: 219266636
Acute myeloid leukemias (AML) that are driven by MLL1 (KMT2A)-fusion proteins (MLL-f) or NPM1 mutations (NPM1mut) are both…
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Review
2018
Review
2018
The clinical significance of FLT3 ITD mutation on the prognosis of adult acute promyelocytic leukemia
Yingchao Fan
,
Yanan Cao
,
X. Bai
,
Wenfang Zhuang
Hematology
2018
Corpus ID: 32725344
ABSTRACT Background and aims: To explore the relationship between FLT3 (encoding Fms related tyrosine kinase 3) internal tandem…
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2015
2015
Effect of vorinostat use on survival in patients with acute myeloid leukemia (AML) with FLT3 ITD mutations.
Y. Chae
,
A. Dimou
,
+12 authors
G. Garcia-Manero
2015
Corpus ID: 78587089
e18019 Background: Novel treatment strategies for patients with AML remain an unmet need. Treatment with vorinostat for three…
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2013
2013
Crenolanib for treating flt3 mutated proliferative disorders
자인 비나이케이.
2013
Corpus ID: 91382671
2013
2013
Inhibiteurs de fak et flt3
M. Devlin
,
I. P. Street
,
W. Tong
2013
Corpus ID: 186653599
L'invention concerne l'utilisation d'un compose de formule (I) : (formule (I)) dans la preparation d'un medicament permettant de…
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2008
2008
Transformation by Oncogenic Mutants and Ligand-Dependent Activation of FLT3 Wild-type Requires the Tyrosine Residues 589 and 591
S. Vempati
,
C. Reindl
,
+7 authors
K. Spiekermann
Clinical Cancer Research
2008
Corpus ID: 10358012
Purpose: Mutations in the receptor tyrosine kinase FLT3 are found in up to 30% of acute myelogenous leukemia patients and are…
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Review
2005
Review
2005
[Mutations of the gene coding for the receptor tyrosine kinase FLT3 in acute myeloid leukemia. Significance as the disease-specific molecular marker for diagnosis, prognosis and innovative therapy…
K. Spiekermann
,
W. Hiddemann
,
S. Schnittger
Deutsche Medizinische Wochenschrift
2005
Corpus ID: 12712920
1999
1999
Early progenitor cells from human mobilized peripheral blood express low levels of the flt3 receptor, but exhibit various biological responses to flt3‐L
T. Aurran-Schleinitz
,
A. Imbert
,
L. Humeau
,
F. Bardin
,
P. Charbord
,
C. Chabannon
British Journal of Haematology
1999
Corpus ID: 21086366
The biological effects of flt3‐L, and the expression of its tyrosine kinase receptor (flt3, CD135) were investigated on the…
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1997
1997
G-CSF-mobilized peripheral blood progenitor cells: in vitro growth pattern and hematopoietic growth factor receptor profile.
A. Roberts
,
M. Zaiss
,
A. Boyd
,
N. Nicola
Experimental Hematology
1997
Corpus ID: 11978823
The kinetics of colony formation by granulocyte colony-stimulating factor (G-CSF)-mobilized peripheral blood progenitor cells…
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