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FL118

National Institutes of Health

Papers overview

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2019
2019
FL118 inhibits viability and induces apoptosis of colorectal cancer cells via inactivating the CIP2A/PP2A axis.
2018
2018
Multiple mechanisms involved in a low concentration of FL118 enhancement of AMR-MeOAc to induce pancreatic cancer cell apoptosis and growth inhibition.
Activating mutations in GTPase protein KRAS occurs in approximately 90% of pancreatic cancers. Mutated KRAS lead to constitutive… 
2016
2016
A novel camptothecin analogue FL 118 reduces cisplatin resistance of non-small cell lung cancer cells
As the first-line drug therapy for non-small cell lung cancer (NSCLC), cisplatin has a wide range of applications. However… 
2015
2015
Use of the FL118 core chemical structure platform to generate FL118 derivatives for treatment of human disease
Described herein, are FLl18 core structure platform compounds, matter of compositions, formulation, methods and uses for treating… 
2014
2014
Abstract 829: The novel camptothecin derivative and IAP inhibitor FL118 is an effective treatment for irinotecan-refractory colorectal cancer
The current standard care for metastatic colorectal cancer is combination of leucovorin, 5-fluorouracil, and irinotecan… 
2014
2014
Abstract 802: Synergistic effect of curcumin on FL118 efficacy in colon cancer
Colorectal cancer is the third most commonly diagnosed cancer in the United States and may cause about 50,830 deaths in 2013… 
2014
2014
Induces p 53-Dependent Senescence in Colorectal Cancer Cells by Promoting Degradation of MdmX
Anticancer agent FL118 was recently identified in screening of small-molecule inhibitors of human survivin expression. Although… 
2013
2013
Abstract 3446: FL118, a survivin/Mcl-1/XIAP/cIAP2-selective inhibitor, effectively inhibits human mesothelioma xenograft growth in animal models.
We have identified and characterized a novel small chemical molecule (designated FL118). Our in vitro studies showed that FL118… 
2012
2012
Abstract 2787: Antitumor activity and toxicity of FL118, a novel IAP/Bcl-2 antiapoptotic genes-selective inhibitor, in animal models of human tumor via the clinic-compatible intravenous (i.v.) routes
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Our previous studies on antitumor activity of… 
2011
2011
Use non-water soluble compounds new formulation and the method for the compound FL118 preparation for treatment of cancer
Compositions is provided, prepares the method for compositions described in the methods and applications of described… 
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