FDPS wt Allele

Known as: FPPS, Farnesyl Diphosphate Synthase wt Allele, Farnesyl Pyrophosphate Synthetase, Dimethylallyltranstransferase, Geranyltranstransferase Gene 
Human FDPS wild-type allele is located in the vicinity of 1q22 and is approximately 12 kb in length. This allele, which encodes farnesyl… (More)
National Institutes of Health

Papers overview

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2009
2009
Considerable effort has focused on the development of selective protein farnesyl transferase (FTase) and protein geranylgeranyl… (More)
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2008
2008
The nitrogen-containing bisphosphonates (N-BPs) are the main drugs currently used to treat diseases characterized by excessive… (More)
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Review
2007
Review
2007
Bisphosphonates (BPs) are well established as the leading drugs for the treatment of osteoporosis. There is new knowledge about… (More)
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Highly Cited
2007
Highly Cited
2007
Interferons initiate the host antiviral response by inducing a number of genes, most with no defined antiviral function. Here we… (More)
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Highly Cited
2007
Highly Cited
2007
Fixed-priority scheduling with deferred preemption (FPDS) has been proposed in the literature as a viable alternative to fixed… (More)
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Highly Cited
2007
Highly Cited
2007
Bisphosphonate drugs (e.g., Fosamax and Zometa) are thought to act primarily by inhibiting farnesyl diphosphate synthase (FPPS… (More)
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Review
2006
Review
2006
The discovery and development of the bisphosphonates (BPs) as a major class of drugs for the treatment of bone diseases has been… (More)
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2006
2006
To understand the structural basis for bisphosphonate therapy of bone diseases, we solved the crystal structures of human… (More)
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Highly Cited
2004
Highly Cited
2004
Farnesyl pyrophosphate synthetase (FPPS) synthesizes farnesyl pyrophosphate through successive condensations of isopentyl… (More)
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2002
2002
A clone encoding farnesyl diphosphate synthase (FPPS) was obtained by PCR from a cDNA library made from young leaves of Artemisia… (More)
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