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Estetrol
Known as:
Estetrol [Chemical/Ingredient]
, 15 alpha-Hydroxyestriol
, Estra-1,3,5(10)-triene-3,15,16,17-tetrol, (15alpha,16alpha,17beta)-
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A metabolite of ESTRIOL with a 15-alpha-hydroxyl group. Estetrol can be converted from estriol sulfate or DEHYDROEPIANDROSTERONE SULFATE by the fetal…
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National Institutes of Health
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Related topics
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8 relations
Estriol
In Blood
agonists
analogs & derivatives
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Adult digit ratio (2D:4D) is not related to umbilical cord androgen or estrogen concentrations, their ratios or net bioactivity.
L. Hollier
,
J. Keelan
,
Esha S L Jamnadass
,
M. Maybery
,
M. Hickey
,
A. Whitehouse
Early Human Development
2015
Corpus ID: 35659277
Highly Cited
2014
Highly Cited
2014
The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation
A. Abot
,
C. Fontaine
,
+26 authors
J. Arnal
EMBO Molecular Medicine
2014
Corpus ID: 5788122
Estetrol (E4) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal…
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Highly Cited
2008
Highly Cited
2008
Oral bioavailability and bone-sparing effects of estetrol in an osteoporosis model
H. Bennink
,
A. Heegaard
,
M. Visser
,
C. Holinka
,
C. Christiansen
Climacteric
2008
Corpus ID: 42275885
Objectives To measure the oral bioavailability of estetrol (E4) in rats relative to its subcutaneous administration and to test…
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Review
2008
Review
2008
Estetrol review: profile and potential clinical applications
H. J. C. Bennink
,
C. Holinka
,
E. Diczfalusy
Climacteric
2008
Corpus ID: 24003341
In this review paper, the existing information on the human fetal steroid estetrol (E4) has been summarized. In the past, E4 was…
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Highly Cited
2008
Highly Cited
2008
First human exposure to exogenous single-dose oral estetrol in early postmenopausal women
M. Visser
,
C. Holinka
,
H. J. C. Bennink
Climacteric
2008
Corpus ID: 23568599
Objective To evaluate the safety, tolerability, pharmacokinetics and effect on gonadotropins of a single escalating dose of…
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Review
2008
Review
2008
In vitro effects of estetrol on receptor binding, drug targets and human liver cell metabolism
M. Visser
,
J. Foidart
,
H. J. T. Coelingh Bennink
Climacteric
2008
Corpus ID: 11027782
In this Appendix, data are reported obtained by in vitro studies, performed with the human fetal steroid estetrol (E4). The…
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Highly Cited
2008
Highly Cited
2008
Estetrol does not bind sex hormone binding globulin or increase its production by human HepG2 cells
Geoffrey L. Hammond
,
K. Hogeveen
,
M. Visser
,
H. J. C. Bennink
Climacteric
2008
Corpus ID: 22715507
Objectives To determine whether human sex hormone binding globulin (SHBG) binds estetrol (E4), and to assess whether E4…
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Review
2008
Review
2008
Estetrol: A unique steroid in human pregnancy
C. Holinka
,
E. Diczfalusy
,
H. Bennink
Journal of Steroid Biochemistry and Molecular…
2008
Corpus ID: 28007341
2006
2006
Determination of steroids in human plasma using temperature-dependent inclusion chromatography for metabolomic investigations.
P. Zarzycki
,
Kathrin M. Kulhanek
,
Roger Smith
,
V. Clifton
Journal of Chromatography A
2006
Corpus ID: 41708850
Highly Cited
1975
Highly Cited
1975
Plasma estetrol as an index of fetal well-being.
Dan Tulchinsky
,
F. Frigoletto
,
Kenneth J. Ryan
,
Jack Fishman
Journal of Clinical Endocrinology and Metabolism
1975
Corpus ID: 2734077
Estetrol (15alpha-hydroxyestriol or E4) is considered to be a specific product of fetal liver and has been suggested as a good…
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