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Estetrol

Known as: Estetrol [Chemical/Ingredient], 15 alpha-Hydroxyestriol, Estra-1,3,5(10)-triene-3,15,16,17-tetrol, (15alpha,16alpha,17beta)- 
A metabolite of ESTRIOL with a 15-alpha-hydroxyl group. Estetrol can be converted from estriol sulfate or DEHYDROEPIANDROSTERONE SULFATE by the fetal… 
National Institutes of Health

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8 relations
EstriolIn Bloodagonistsanalogs & derivatives

Papers overview

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Highly Cited
2015
Highly Cited
2015
Adult digit ratio (2D:4D) is not related to umbilical cord androgen or estrogen concentrations, their ratios or net bioactivity.
Highly Cited
2014
Highly Cited
2014
The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation
Estetrol (E4) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal… 
Highly Cited
2008
Highly Cited
2008
Oral bioavailability and bone-sparing effects of estetrol in an osteoporosis model
Objectives To measure the oral bioavailability of estetrol (E4) in rats relative to its subcutaneous administration and to test… 
Review
2008
Review
2008
Estetrol review: profile and potential clinical applications
In this review paper, the existing information on the human fetal steroid estetrol (E4) has been summarized. In the past, E4 was… 
Highly Cited
2008
Highly Cited
2008
First human exposure to exogenous single-dose oral estetrol in early postmenopausal women
Objective To evaluate the safety, tolerability, pharmacokinetics and effect on gonadotropins of a single escalating dose of… 
Review
2008
Review
2008
In vitro effects of estetrol on receptor binding, drug targets and human liver cell metabolism
In this Appendix, data are reported obtained by in vitro studies, performed with the human fetal steroid estetrol (E4). The… 
Highly Cited
2008
Highly Cited
2008
Estetrol does not bind sex hormone binding globulin or increase its production by human HepG2 cells
Objectives To determine whether human sex hormone binding globulin (SHBG) binds estetrol (E4), and to assess whether E4… 
Review
2008
Review
2008
Estetrol: A unique steroid in human pregnancy
2006
2006
Determination of steroids in human plasma using temperature-dependent inclusion chromatography for metabolomic investigations.
Highly Cited
1975
Highly Cited
1975
Plasma estetrol as an index of fetal well-being.
Estetrol (15alpha-hydroxyestriol or E4) is considered to be a specific product of fetal liver and has been suggested as a good… 
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