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Escalation

Known as: Escalate 
An increase in extent or intensity; to become more serious.
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Phase II study of thalidomide in patients with unresectable hepatocellular carcinoma
The hypervascular nature of hepatocellular carcinoma (HCC) is well characterized. Recent data have suggested that thalidomide… 
Highly Cited
2003
Highly Cited
2003
Preliminary evaluation of low-grade toxicity with conformal radiation therapy for prostate cancer on RTOG 9406 dose levels I and II.
Highly Cited
2002
Highly Cited
2002
Daily targeting of intrahepatic tumors for radiotherapy.
Highly Cited
2001
Highly Cited
2001
Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms.
PURPOSE To define the maximum tolerated dose (MTD) and dose-limiting toxicity (DLT) of the novel protein kinase inhibitor, UCN-01… 
Highly Cited
2000
Highly Cited
2000
Randomized, dose-escalation study of SD/01 compared with daily filgrastim in patients receiving chemotherapy.
PURPOSE To explore the use of SD/01 (a polyethylene glycol-conjugated filgrastim shown in preclinical studies to have a prolonged… 
Highly Cited
1998
Highly Cited
1998
The dark side of alliances:: Lessons from Volvo–Renault
Review
1997
Review
1997
Potential clinical impact of normal-tissue intrinsic radiosensitivity testing.
Review
1997
Review
1997
Monitoring of opioid therapy in advanced cancer pain patients.
Highly Cited
1995
Highly Cited
1995
Preliminary results of a prospective trial using three dimensional radiotherapy for lung cancer.
Highly Cited
1995
Highly Cited
1995
Initial phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, using the modified continual reassessment method for dose escalation.
PURPOSE To determine the toxicities, maximal-tolerated dose (MTD), pharmacokinetic profile, and potential antitumor activity of… 
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