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Escalation

Known as: Escalate 
An increase in extent or intensity; to become more serious.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Inhibition of mutated, activated BRAF in metastatic melanoma.
BACKGROUND The identification of somatic mutations in the gene encoding the serine-threonine protein kinase B-RAF (BRAF) in the… 
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Review
2009
Review
2009
Dose Escalation Methods in Phase I Cancer Clinical Trials
Phase I clinical trials are an essential step in the development of anticancer drugs. The main goal of these studies is to… 
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Highly Cited
2006
Highly Cited
2006
Dose escalation of a curcuminoid formulation
BackgroundCurcumin is the major yellow pigment extracted from turmeric, a commonly-used spice in India and Southeast Asia that… 
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Highly Cited
2004
Highly Cited
2004
B cell depletion as a novel treatment for systemic lupus erythematosus: a phase I/II dose-escalation trial of rituximab.
OBJECTIVE Safer and more effective therapies are needed for the treatment of systemic lupus erythematosus (SLE). B lymphocytes… 
Highly Cited
2004
Highly Cited
2004
The Healthcare Costs of Sarcopenia in the United States
Objectives: To estimate the healthcare costs of sarcopenia in the United States and to examine the effect that a reduced… 
Highly Cited
2001
Highly Cited
2001
The Mutual Knowledge Problem and Its Consequences for Dispersed Collaboration
This paper proposes that maintaining "mutual knowledge" is a central problem of geographically dispersed collaboration and traces… 
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Highly Cited
2001
Highly Cited
2001
Rituximab dose-escalation trial in chronic lymphocytic leukemia.
PURPOSE To conduct a dose-escalation trial of rituximab in patients with chronic lymphocytic leukemia (CLL) to define the maximum… 
Highly Cited
1999
Highly Cited
1999
Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial.
CONTEXT The protein hormone leptin is important to the homeostatic regulation of body weight. Treatment with exogenous leptin may… 
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Highly Cited
1995
Highly Cited
1995
Preventing escalation in problem behaviors with high-risk young adolescents: immediate and 1-year outcomes.
The study tested alternative intervention strategies to reduce escalation in problem behaviors among high-risk young adolescents… 
Highly Cited
1974
Highly Cited
1974
Assessment strategy and the evolution of fighting behaviour.
  • G. Parker
  • Journal of theoretical biology
  • 1974
  • Corpus ID: 12222842
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