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Epidermal Growth Factor Receptor Pathway Substrate 15

Known as: Epidermal Growth Factor Receptor Pathway Substrate-15, Protein EPS15, EPS15 
Epidermal growth factor receptor pathway substrate 15; has a role in normal and neoplastic cell proliferation. (LocusLink)
National Institutes of Health

Related topics

Related topics

7 relations
Cell ProliferationEPS15 geneHomo sapiensSignal Transduction

Papers overview

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Highly Cited
2012
Highly Cited
2012
The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin β1 endocytosis
Dab2 binds EH domain proteins. This interaction is required for integrin β1 but not TfnR endocytosis. β1 and TfnR do not… 
Highly Cited
2009
Highly Cited
2009
Eps15 interacts with ubiquitinated Cx43 and mediates its internalization.
Highly Cited
2006
Highly Cited
2006
A Deubiquitinating Enzyme UBPY Regulates the Level of Protein Ubiquitination on Endosomes
Monoubiquitination of endocytosed cell surface receptors serves as a sorting signal for their trafficking from endosomes to… 
Highly Cited
2002
Highly Cited
2002
Interactions of Phocein with Nucleoside-Diphosphate Kinase, Eps15, and Dynamin I*
Phocein, an intracellular protein interacting with striatin, bears a few homologies with the ς-subunits of clathrin adaptor… 
Highly Cited
2000
Highly Cited
2000
Polyubiquitination of the Epidermal Growth Factor Receptor Occurs at the Plasma Membrane upon Ligand-induced Activation*
We have previously shown that, although overexpression of mutant dynamin inhibits clathrin-dependent endocytosis and disrupts… 
Highly Cited
1998
Highly Cited
1998
Assembly of Clathrin Coats Disrupts the Association between Eps15 and AP-2 Adaptors*
Eps15 is a phosphorylation substrate of the epidermal growth factor receptor kinase. In vivo, it is largely found in complex with… 
Highly Cited
1997
Highly Cited
1997
Epidermal Growth Factor Induces Ubiquitination of Eps15*
Epidermal growth factor (EGF) receptor pathway substrate clone 15 (Eps15) has been described as a 142-kDa EGF receptor substrate… 
Highly Cited
1997
Highly Cited
1997
eps15 and eps15R are essential components of the endocytic pathway.
eps15 and eps1SR are substrates of the epidermal growth factor (EGF) receptor kinase that are characterized by the presence of a… 
Highly Cited
1997
Highly Cited
1997
Association and Colocalization of Eps15 with Adaptor Protein-2 and Clathrin
Eps15 has been identified as a substrate of the EGF receptor tyrosine kinase. In this report, we show that activation of the EGF… 
Highly Cited
1997
Highly Cited
1997
Eps15 Is Constitutively Oligomerized Due to Homophilic Interaction of Its Coiled-coil Region*
Eps15 is a member of an emerging family of proteins containing a novel protein/protein interaction domain, the EH domain, of as… 
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