Enzyme Therapy

Known as: Enzyme Therapies, Therapies, Enzyme, Therapy, Enzyme 
The use of enzymes to correct metabolic and physiological processes.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1947-2018
0102019472017

Papers overview

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2011
2011
BACKGROUND In Gaucher disease (GD), acid-β-glucosidase (GBA1) gene mutations result in defective glucocerebrosidase and variable… (More)
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Highly Cited
2008
Highly Cited
2008
Gaucher's disease continues to be a model for applications of molecular medicine to clinical delineation, diagnosis, and… (More)
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Highly Cited
2007
Highly Cited
2007
Treatment of brain disease with recombinant proteins is difficult due to the blood-brain barrier. As an alternative to direct… (More)
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Highly Cited
2007
Highly Cited
2007
An approach to treating Gaucher disease is substrate inhibition therapy which seeks to abate the aberrant lysosomal accumulation… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Fabry disease is an X-linked inherited disorder that is caused by excessive lysosomal globotriaosylceramide (CTH… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Although studies have suggested that "late-onset" hypertrophic cardiomyopathy (HCM) may be caused by sarcomeric… (More)
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Highly Cited
2002
Highly Cited
2002
To the editor—Severe combined immunodeficiency (SCID) due to adenosine deaminase (ADA) deficiency was the first genetic disease… (More)
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Highly Cited
2001
Highly Cited
2001
Purpose: Infantile glycogen storage disease type II (GSD-II) is a fatal genetic muscle disorder caused by deficiency of acid… (More)
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1999
1999
Alglucerase, a macrophage-targeted enzyme replacement therapy for Gaucher disease, has been successfully used for several years… (More)
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Highly Cited
1993
Highly Cited
1993
Gaucher disease is the most frequent lysosomal storage disease and the most prevalent genetic disease among the Ashkenazi Jews (q… (More)
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