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Enediyne Antineoplastic Antibiotic

An enediyne antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. After cycloaromatization, the enediyne… Expand
National Institutes of Health

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2018
2018
A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
Dynemicin A is a member of a subfamily of enediyne antitumor antibiotics characterized by a 10-membered carbocycle fused to an… Expand
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2009
2009
Exploration and engineering of biosynthetic pathways in the marine actinomycete Salinispora tropica
In recent years, members of the marine actinomycete genus Salinispora have proven to be a precious source of structurally diverse… Expand
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2009
2009
Enediyne lidamycin induces apoptosis in human multiple myeloma cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase
In the present study, the effects of lidamycin (LDM), a member of the enediyne antibiotic family, on two human multiple myeloma… Expand
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2007
2007
Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic.
The enediyne chromoproteins are a class of potent antitumour antibiotics comprising a 1:1 complex of a protein and a… Expand
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2006
2006
Synthesis of bowl-shaped polycyclic aromatic hydrocarbons via palladium-catalyzed intramolecular arylation reactions.
[reaction: see text] Treatment of the benzannulated enediyne 11 with potassium tert-butoxide in refluxing toluene for 12 h… Expand
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2006
2006
Antitumor enediyne chromoprotein C-1027: mechanistic investigation of the chromophore-mediated self-decomposition pathway.
C-1027 is an extremely potent antitumor agent that causes double-stranded DNA cleavages. It is a unique small molecule-protein… Expand
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2005
2005
Application of photochemical decarbonylation of cyclopropenones for the in situ generation of reactive enediynes. Construction of a cyclopropenone-containing enediyne precursor by using a…
[reaction: see text] A cyclopropenone-containing enediyne photoprecursor, 6-tert-butyldimethylsilyloxy-3-(alpha-hydroxybenzyl… Expand
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2003
2003
In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein.
Neocarzinostatin is the most studied member of the enediyne-chromoprotein family, and is clinically used as an antitumoral agent… Expand
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2002
2002
Ruthenium-mediated cycloaromatization of acyclic enediynes and dienynes at ambient temperature.
The ruthenium(II) cation, [Cp*Ru(NCMe)3]OTf (4), triggers the Bergman cycloaromatization of acyclic endiynes at room temperature… Expand
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2001
2001
The contribution of ligand flexibility to metal center geometry modulated thermal cyclization of conjugated pyridine and quinoline metalloenediynes of copper(I) and copper(II).
We report the syntheses, reactivities, and structure evaluations of a series of Cu(I) and Cu(II) metalloenediynes of conjugated 1… Expand
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