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Enediyne Antineoplastic Antibiotic

An enediyne antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. After cycloaromatization, the enediyne… 
National Institutes of Health

Papers overview

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2009
2009
Enediyne lidamycin induces apoptosis in human multiple myeloma cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase
In the present study, the effects of lidamycin (LDM), a member of the enediyne antibiotic family, on two human multiple myeloma… 
2006
2006
Synthesis of bowl-shaped polycyclic aromatic hydrocarbons via palladium-catalyzed intramolecular arylation reactions.
[reaction: see text] Treatment of the benzannulated enediyne 11 with potassium tert-butoxide in refluxing toluene for 12 h… 
2006
2006
Antitumor enediyne chromoprotein C-1027: mechanistic investigation of the chromophore-mediated self-decomposition pathway.
C-1027 is an extremely potent antitumor agent that causes double-stranded DNA cleavages. It is a unique small molecule-protein… 
2006
2006
Synthesis and DNA cleavage reaction characteristics of enediyne prodrugs activated via an allylic rearrangement by base or UV irradiation.
2005
2005
Application of photochemical decarbonylation of cyclopropenones for the in situ generation of reactive enediynes. Construction of a cyclopropenone-containing enediyne precursor by using a…
[reaction: see text] A cyclopropenone-containing enediyne photoprecursor, 6-tert-butyldimethylsilyloxy-3-(alpha-hydroxybenzyl… 
2003
2003
In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein.
Neocarzinostatin is the most studied member of the enediyne-chromoprotein family, and is clinically used as an antitumoral agent… 
2002
2002
Ruthenium-mediated cycloaromatization of acyclic enediynes and dienynes at ambient temperature.
The ruthenium(II) cation, [Cp*Ru(NCMe)3]OTf (4), triggers the Bergman cycloaromatization of acyclic endiynes at room temperature… 
2001
2001
The contribution of ligand flexibility to metal center geometry modulated thermal cyclization of conjugated pyridine and quinoline metalloenediynes of copper(I) and copper(II).
We report the syntheses, reactivities, and structure evaluations of a series of Cu(I) and Cu(II) metalloenediynes of conjugated 1… 
1997
1997
Enediyne-lexitropsin DNA-targeted anticancer agents. Physicochemical and cytotoxic properties in human neoplastic cells in vitro, and intracellular distribution.
Two series of hybrids of a dynemicin A model and DNA minor groove binding lexitropsins were synthesized and their cytotoxic… 
1996
1996
Synthesis, Structure, and Reactivity of Enediyne Macrocycles.
The reaction of bis-propargyl bromide enediyne 4 with weakly basic nucleophiles allows the facile synthesis of acyclic and… 
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