Enediyne Antineoplastic Antibiotic
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Dynemicin A is a member of a subfamily of enediyne antitumor antibiotics characterized by a 10-membered carbocycle fused to an… Expand Polyalkyne and enediyne azamacrocycles are prepared from arenesulfonamides and various alkyne and alkene derivatives either under… Expand The enediyne chromoproteins are a class of potent antitumour antibiotics comprising a 1:1 complex of a protein and a… Expand [reaction: see text] Treatment of the benzannulated enediyne 11 with potassium tert-butoxide in refluxing toluene for 12 h… Expand [reaction: see text] A cyclopropenone-containing enediyne photoprecursor, 6-tert-butyldimethylsilyloxy-3-(alpha-hydroxybenzyl… Expand Neocarzinostatin is the most studied member of the enediyne-chromoprotein family, and is clinically used as an antitumoral agent… Expand The ruthenium(II) cation, [Cp*Ru(NCMe)3]OTf (4), triggers the Bergman cycloaromatization of acyclic endiynes at room temperature… Expand We report the syntheses, reactivities, and structure evaluations of a series of Cu(I) and Cu(II) metalloenediynes of conjugated 1… Expand The synthesis and evaluation of the 4-nitrobenzylcarbamate enediyne 6 and related compounds as prodrugs activated by a… Expand BACKGROUND
Enediyne chromoproteins are potent antitumor antibiotic agents. They consist of a labile nine-membered enediyne… Expand