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Enediyne Antineoplastic Antibiotic

An enediyne antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. After cycloaromatization, the enediyne… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2018
01219952018

Papers overview

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2018
2018
A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
Dynemicin A is a member of a subfamily of enediyne antitumour antibiotics characterized by a 10-membered carbocycle fused to an… (More)
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2014
2014
An EGFR/CD13 bispecific fusion protein and its enediyne-energized analog show potent antitumor activity.
Targeting to two or more objectives simultaneously has been pursued as a strategy to potentially increase the efficiency and… (More)
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2014
2014
The radiomimetic enediyne, 20'-deschloro-C-1027 induces inter-strand DNA crosslinks in hypoxic cells and overcomes cytotoxic radioresistance.
The ability of the radiomimetic anti-tumor enediyne C-1027 to induce DNA inter-strand crosslinks (ICLs), in addition to the… (More)
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2009
2009
Enediyne lidamycin induces apoptosis in human multiple myeloma cells through activation of p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase.
In the present study, the effects of lidamycin (LDM), a member of the enediyne antibiotic family, on two human multiple myeloma… (More)
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2007
2007
Protein-small molecule interactions in neocarzinostatin, the prototypical enediyne chromoprotein antibiotic.
The enediyne chromoproteins are a class of potent antitumour antibiotics comprising a 1:1 complex of a protein and a… (More)
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2006
2006
Antitumor enediyne chromoprotein C-1027: mechanistic investigation of the chromophore-mediated self-decomposition pathway.
C-1027 is an extremely potent antitumor agent that causes double-stranded DNA cleavages. It is a unique small molecule-protein… (More)
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2003
2003
In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein.
Neocarzinostatin is the most studied member of the enediyne-chromoprotein family, and is clinically used as an antitumoral agent… (More)
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2001
2001
DNA damage by the enediyne C-1027 results in the inhibition of DNA replication by loss of replication protein A function and activation of DNA-dependent protein kinase.
Treatment of cells with the enediyne C-1027 is highly efficient at inducing single- and double-strand DNA breaks. This agent is… (More)
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1996
1996
Synthesis, Structure, and Reactivity of Enediyne Macrocycles.
The reaction of bis-propargyl bromide enediyne 4 with weakly basic nucleophiles allows the facile synthesis of acyclic and… (More)
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1995
1995
The proteolytic specificity of the natural enediyne-containing chromoproteins is unique to each chromoprotein.
BACKGROUND Enediyne chromoproteins are potent antitumor antibiotic agents. They consist of a labile nine-membered enediyne… (More)
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