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Enediyne Antineoplastic Antibiotic
An enediyne antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. After cycloaromatization, the enediyne…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
Douglas R. Cohen
,
C. Townsend
Nature chemistry
2018
Corpus ID: 205298516
Dynemicin A is a member of a subfamily of enediyne antitumor antibiotics characterized by a 10-membered carbocycle fused to an…
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Review
2010
Review
2010
[2+2+2] Cycloaddition Reactions of Macrocyclic Systems Catalyzed by Transition Metals. A Review
A. Pla-Quintana
,
A. Roglans
Molecules
2010
Corpus ID: 15328435
Polyalkyne and enediyne azamacrocycles are prepared from arenesulfonamides and various alkyne and alkene derivatives either under…
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2007
2007
Protein–Small Molecule Interactions in Neocarzinostatin, the Prototypical Enediyne Chromoprotein Antibiotic
J. R. Baker
,
D. Woolfson
,
F. Muskett
,
Rhys G. Stoneman
,
Michael D. Urbaniak
,
S. Caddick
Chembiochem : a European journal of chemical…
2007
Corpus ID: 11254706
The enediyne chromoproteins are a class of potent antitumour antibiotics comprising a 1:1 complex of a protein and a…
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2006
2006
Synthesis of bowl-shaped polycyclic aromatic hydrocarbons via palladium-catalyzed intramolecular arylation reactions.
Daehwan Kim
,
J. L. Petersen
,
Kung K Wang
Organic letters
2006
Corpus ID: 12261566
[reaction: see text] Treatment of the benzannulated enediyne 11 with potassium tert-butoxide in refluxing toluene for 12 h…
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Review
2005
Review
2005
Astonishing diversity of natural surfactants: 6. Biologically active marine and terrestrial alkaloid glycosides
V. Dembitsky
Lipids
2005
Corpus ID: 3976761
This review article presents 209 alkaloid glycosides isolated and identified from plants, microorganisms, and marine…
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2003
2003
In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein.
Bernadette Heyd
,
F. Pecorari
,
B. Collinet
,
E. Adjadj
,
M. Desmadril
,
P. Minard
Biochemistry
2003
Corpus ID: 532524
Neocarzinostatin is the most studied member of the enediyne-chromoprotein family, and is clinically used as an antitumoral agent…
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2002
2002
Ruthenium-mediated cycloaromatization of acyclic enediynes and dienynes at ambient temperature.
J. O’Connor
,
Seth J. Friese
,
Mark S Tichenor
Journal of the American Chemical Society
2002
Corpus ID: 46586132
The ruthenium(II) cation, [Cp*Ru(NCMe)3]OTf (4), triggers the Bergman cycloaromatization of acyclic endiynes at room temperature…
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2001
2001
The contribution of ligand flexibility to metal center geometry modulated thermal cyclization of conjugated pyridine and quinoline metalloenediynes of copper(I) and copper(II).
D. Rawat
,
P. Benites
,
C. Incarvito
,
A. Rheingold
,
J. Zaleski
Inorganic chemistry
2001
Corpus ID: 10782718
We report the syntheses, reactivities, and structure evaluations of a series of Cu(I) and Cu(II) metalloenediynes of conjugated 1…
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1999
1999
Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).
M. Hay
,
W. Wilson
,
W. Denny
Bioorganic & medicinal chemistry letters
1999
Corpus ID: 34077002
1995
1995
The proteolytic specificity of the natural enediyne-containing chromoproteins is unique to each chromoprotein.
N. Zein
,
P. Reiss
,
M. Bernatowicz
,
M. Bolgar
Chemistry & biology
1995
Corpus ID: 25788709
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