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Enediyne Antineoplastic Antibiotic

An enediyne antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. After cycloaromatization, the enediyne… Expand
National Institutes of Health

Papers overview

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2018
2018
A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
Dynemicin A is a member of a subfamily of enediyne antitumor antibiotics characterized by a 10-membered carbocycle fused to an… Expand
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Review
2010
Review
2010
[2+2+2] Cycloaddition Reactions of Macrocyclic Systems Catalyzed by Transition Metals. A Review
Polyalkyne and enediyne azamacrocycles are prepared from arenesulfonamides and various alkyne and alkene derivatives either under… Expand
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2007
2007
Protein–Small Molecule Interactions in Neocarzinostatin, the Prototypical Enediyne Chromoprotein Antibiotic
The enediyne chromoproteins are a class of potent antitumour antibiotics comprising a 1:1 complex of a protein and a… Expand
2006
2006
Synthesis of bowl-shaped polycyclic aromatic hydrocarbons via palladium-catalyzed intramolecular arylation reactions.
[reaction: see text] Treatment of the benzannulated enediyne 11 with potassium tert-butoxide in refluxing toluene for 12 h… Expand
2005
2005
Application of photochemical decarbonylation of cyclopropenones for the in situ generation of reactive enediynes. Construction of a cyclopropenone-containing enediyne precursor by using a…
[reaction: see text] A cyclopropenone-containing enediyne photoprecursor, 6-tert-butyldimethylsilyloxy-3-(alpha-hydroxybenzyl… Expand
2003
2003
In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein.
Neocarzinostatin is the most studied member of the enediyne-chromoprotein family, and is clinically used as an antitumoral agent… Expand
2002
2002
Ruthenium-mediated cycloaromatization of acyclic enediynes and dienynes at ambient temperature.
The ruthenium(II) cation, [Cp*Ru(NCMe)3]OTf (4), triggers the Bergman cycloaromatization of acyclic endiynes at room temperature… Expand
2001
2001
The contribution of ligand flexibility to metal center geometry modulated thermal cyclization of conjugated pyridine and quinoline metalloenediynes of copper(I) and copper(II).
We report the syntheses, reactivities, and structure evaluations of a series of Cu(I) and Cu(II) metalloenediynes of conjugated 1… Expand
1999
1999
Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).
The synthesis and evaluation of the 4-nitrobenzylcarbamate enediyne 6 and related compounds as prodrugs activated by a… Expand
1995
1995
The proteolytic specificity of the natural enediyne-containing chromoproteins is unique to each chromoprotein.
BACKGROUND Enediyne chromoproteins are potent antitumor antibiotic agents. They consist of a labile nine-membered enediyne… Expand
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