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Enediyne Antineoplastic Antibiotic

An enediyne antineoplastic antibiotic isolated from Streptomyces bacterial species or derived synthetically. After cycloaromatization, the enediyne… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
A dual role for a polyketide synthase in dynemicin enediyne and anthraquinone biosynthesis
Dynemicin A is a member of a subfamily of enediyne antitumor antibiotics characterized by a 10-membered carbocycle fused to an… 
Review
2010
Review
2010
[2+2+2] Cycloaddition Reactions of Macrocyclic Systems Catalyzed by Transition Metals. A Review
Polyalkyne and enediyne azamacrocycles are prepared from arenesulfonamides and various alkyne and alkene derivatives either under… 
2007
2007
Protein–Small Molecule Interactions in Neocarzinostatin, the Prototypical Enediyne Chromoprotein Antibiotic
The enediyne chromoproteins are a class of potent antitumour antibiotics comprising a 1:1 complex of a protein and a… 
2006
2006
Synthesis of bowl-shaped polycyclic aromatic hydrocarbons via palladium-catalyzed intramolecular arylation reactions.
[reaction: see text] Treatment of the benzannulated enediyne 11 with potassium tert-butoxide in refluxing toluene for 12 h… 
Review
2005
Review
2005
Astonishing diversity of natural surfactants: 6. Biologically active marine and terrestrial alkaloid glycosides
This review article presents 209 alkaloid glycosides isolated and identified from plants, microorganisms, and marine… 
2003
2003
In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein.
Neocarzinostatin is the most studied member of the enediyne-chromoprotein family, and is clinically used as an antitumoral agent… 
2002
2002
Ruthenium-mediated cycloaromatization of acyclic enediynes and dienynes at ambient temperature.
The ruthenium(II) cation, [Cp*Ru(NCMe)3]OTf (4), triggers the Bergman cycloaromatization of acyclic endiynes at room temperature… 
2001
2001
The contribution of ligand flexibility to metal center geometry modulated thermal cyclization of conjugated pyridine and quinoline metalloenediynes of copper(I) and copper(II).
We report the syntheses, reactivities, and structure evaluations of a series of Cu(I) and Cu(II) metalloenediynes of conjugated 1… 
1999
1999
Nitrobenzyl carbamate prodrugs of enediynes for nitroreductase gene-directed enzyme prodrug therapy (GDEPT).
1995
1995
The proteolytic specificity of the natural enediyne-containing chromoproteins is unique to each chromoprotein.
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