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Endothelin A Receptor Antagonists
Known as:
Antagonists, Endothelin A Receptor
, Endothelin Receptor Type A Antagonist
, Endothelin A Receptor Blockers
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A substance that blocks the binding of the endothelin-1 protein to its receptor. Endothelin-1 is a small molecule that causes changes in blood…
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National Institutes of Health
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7 relations
Narrower (3)
HJP 278
HJP 286
Macitentan
In Blood
aspects of radiation effects
chemical synthesis
standards characteristics
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Preclinical anticancer activity of the specific endothelin A receptor antagonist ZD4054
J. Growcott
Anti-Cancer Drugs
2009
Corpus ID: 205527510
Endothelins are a family of small peptides (ET-1, ET-2, and ET-3) that mediate various physiological processes of mitogenesis…
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Highly Cited
2002
Highly Cited
2002
The Signal Peptide of the G Protein-coupled Human Endothelin B Receptor Is Necessary for Translocation of the N-terminal Tail across the Endoplasmic Reticulum Membrane*
Robert Köchl
,
M. Alken
,
+4 authors
R. Schülein
Journal of Biological Chemistry
2002
Corpus ID: 25369013
The initial step of the intracellular transport of G protein-coupled receptors, their insertion into the membrane of the…
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Highly Cited
2002
Highly Cited
2002
The Extracellular N Terminus of the Endothelin B (ETB) Receptor Is Cleaved by a Metalloprotease in an Agonist-dependent Process*
E. Grantcharova
,
J. Furkert
,
+6 authors
A. Oksche
Journal of Biological Chemistry
2002
Corpus ID: 2530555
The extracellular N terminus of the endothelin B (ETB) receptor is susceptible to limited proteolysis (cleavage at R64↓S65), but…
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Highly Cited
1998
Highly Cited
1998
Differential Activity of the G Protein β5γ2 Subunit at Receptors and Effectors*
M. Lindorfer
,
C. Myung
,
Y. Savino
,
H. Yasuda
,
Rimma Khazan
,
J. Garrison
Journal of Biological Chemistry
1998
Corpus ID: 35452971
The G protein β5 subunit differs substantially in amino acid sequence from the other known β subunits suggesting that βγ dimers…
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Highly Cited
1998
Highly Cited
1998
Endothelin A receptor blockade causes adverse left ventricular remodeling but improves pulmonary artery pressure after infarction in the rat.
Q. Nguyen
,
P. Cernacek
,
+5 authors
J. Rouleau
Circulation
1998
Corpus ID: 1589379
BACKGROUND Endothelin A (ETA) receptor antagonists have been shown to improve ventricular remodeling and survival in rats when…
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Highly Cited
1997
Highly Cited
1997
Design of a potent combined pseudopeptide endothelin-A/endothelin-B receptor antagonist, Ac-DBhg16-Leu-Asp-Ile-[NMe]Ile-Trp21 (PD 156252): examination of its pharmacokinetic and spectral properties.
W. L. Cody
,
J. He
,
+5 authors
A. Doherty
Journal of Medicinal Chemistry
1997
Corpus ID: 45100362
The endothelins (ETs) are a family of bicyclic 21-amino acid peptides that are potent and prolonged vasoconstrictors. It has been…
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Highly Cited
1996
Highly Cited
1996
Enhanced coronary vasoconstriction to endothelin-B-receptor activation in experimental congestive heart failure.
C. Cannan
,
John C. Bumett
,
auAmir Lerman
Circulation
1996
Corpus ID: 45691400
Highly Cited
1996
Highly Cited
1996
Role of endothelin in mediating neurogenic plasma extravasation in rat dura mater
P. Brändli
,
B. Löffler
,
V. Breu
,
R. Osterwalder
,
J. Maire
,
M. Clozel
Pain
1996
Corpus ID: 6977447
Highly Cited
1989
Highly Cited
1989
Two distinct types of endothelin receptors are present on chick cardiac membranes.
H. Watanabe
,
H. Miyazaki
,
+5 authors
K. Murakami
Biochemical and Biophysical Research…
1989
Corpus ID: 37558700
Highly Cited
1988
Highly Cited
1988
Effects of endothelin in the systemic and renal vascular beds in vivo.
H. Lippton
,
J. Goff
,
A. Hyman
European Journal of Pharmacology
1988
Corpus ID: 33490324
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