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EZN-4176

Known as: Androgen Receptor Antisense Oligonucleotide EZN-4176 
A locked nucleic acid (LNA)-based antisense oligonucleotide targeting the androgen receptor (AR) mRNA, with potential antineoplastic activity. Upon… 
National Institutes of Health

Papers overview

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2016
2016
Voie de signalisation des androgènes, altérations génomiques et progression du cancer de la prostate
La voie de signalisation du recepteur des androgenes (RA) reste une cible therapeutique privilegiee dans les cancers de la… 
2013
2013
First-in-human phase I study of EZN-4176, a locked nucleic acid antisense oligonucleotide (LNA-ASO) to androgen receptor (AR) mRNA in patients with castration-resistant prostate cancer (CRPC).
5052 Background: EZN-4176 is a third generationLNA-ASO that binds the ligand binding domain of AR mRNA resulting in full length… 
2013
2013
Prostate cancer: Antisense nucleic acids—tough delivery
First-in-human data of the locked antisense oligonucleotide (ASO) EZN4176, which binds exon 4 of the androgen receptor (AR) mRNA… 
2011
2011
Abstract 5394: Dual inhibition of the androgen receptor by ligand blockade and antisense-mediated downregulation is associated with synergistic antitumor activity model of prostate cancer
Background: Although new agents to treat prostate cancer have recently been approved, and new investigational drugs (Abiraterone… 
2010
2010
Abstract 602: Silencing of the androgen receptor (AR) with a novel mRNA antisense oligonucleotide causes antitumor effects in xenograft models of prostate cancer
Background: The AR is a ligand-activated transcriptional factor that plays an important role in prostate cancer. While androgen… 
2010
2010
218 Down-modulation of the androgen receptor (AR) with EZN-4176 inhibits the growth of prostate tumor and potentiates the inhibitory effect of MDV-3100, a novel anti-androgen
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