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EZN 3042

Known as: Survivin mRNA Antagonist EZN-3042, EZN-3042, EZN3042 
A locked nucleic acid (LNA) antisense oligonucleotide targeting survivin mRNA, with potential antineoplastic activity. EZN-3042 hybridizes to… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Background Lymphoma is a common cancer in dogs. While most dogs receiving chemotherapy experience remission, very few are cured… Expand
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2016
2016
Canine lymphoma (LSA) and osteosarcoma (OS) have high mortality rates and remain in need of more effective therapeutic approaches… Expand
2014
2014
To address the therapeutic challenges in childhood relapsed ALL, a phase 1 study combining a survivin mRNA antagonist, EZN-3042… Expand
2013
2013
A 23 y/o female admitted with complaints of fewer, dyspnea, and cough for a month. She was diagnosed systemic lupus erytematotus… Expand
2013
2013
Background: Survivin, a member of the apoptosis protein inhibitor family, is an essential regulator of cell division and a… Expand
Highly Cited
2011
Highly Cited
2011
Relapse of drug-resistant acute lymphoblastic leukemia (ALL) has been associated with increased expression of survivin/BIRC5, an… Expand
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2011
2011
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background : Survivin, the smallest member of the… Expand
2011
2011
A th W T l h 1 A it P t ik 1 K i k P P d l 1 J A 1 F i M L ki 2 K R ï 2 St K l b k † Ab B hbi d 3* Poster A216 n ony . o c er, m… Expand
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2010
2010
Survivin plays an important role in preventing apoptosis and permitting mitosis, and is highly expressed in various human cancers… Expand
2008
2008
1) EZN-3042 displayed potent in vitro knockdown of survivin mRNA and growth inhibition of several human cancer cell lines (IC50… Expand