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EZN 3042

Known as: Survivin mRNA Antagonist EZN-3042, EZN-3042, EZN3042 
A locked nucleic acid (LNA) antisense oligonucleotide targeting survivin mRNA, with potential antineoplastic activity. EZN-3042 hybridizes to… Expand
National Institutes of Health

Papers overview

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2020
2020
Background Lymphoma is a common cancer in dogs. While most dogs receiving chemotherapy experience remission, very few are cured… Expand
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2016
2016
Canine lymphoma (LSA) and osteosarcoma (OS) have high mortality rates and remain in need of more effective therapeutic approaches… Expand
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2014
2014
To address the therapeutic challenges in childhood relapsed ALL, a phase 1 study combining a survivin mRNA antagonist, EZN-3042… Expand
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2013
2013
A 23 y/o female admitted with complaints of fewer, dyspnea, and cough for a month. She was diagnosed systemic lupus erytematotus… Expand
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2013
2013
Background: Survivin, a member of the apoptosis protein inhibitor family, is an essential regulator of cell division and a… Expand
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Highly Cited
2011
Highly Cited
2011
Relapse of drug-resistant acute lymphoblastic leukemia (ALL) has been associated with increased expression of survivin/BIRC5, an… Expand
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2011
2011
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background : Survivin, the smallest member of the… Expand
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2011
2011
A th W T l h 1 A it P t ik 1 K i k P P d l 1 J A 1 F i M L ki 2 K R ï 2 St K l b k † Ab B hbi d 3* Poster A216 n ony . o c er, m… Expand
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2010
2010
Survivin plays an important role in preventing apoptosis and permitting mitosis, and is highly expressed in various human cancers… Expand
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2008
2008
1) EZN-3042 displayed potent in vitro knockdown of survivin mRNA and growth inhibition of several human cancer cell lines (IC50… Expand
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