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Background Lymphoma is a common cancer in dogs. While most dogs receiving chemotherapy experience remission, very few are cured… Expand Canine lymphoma (LSA) and osteosarcoma (OS) have high mortality rates and remain in need of more effective therapeutic approaches… Expand To address the therapeutic challenges in childhood relapsed ALL, a phase 1 study combining a survivin mRNA antagonist, EZN-3042… Expand A 23 y/o female admitted with complaints of fewer, dyspnea, and cough for a month. She was diagnosed systemic lupus erytematotus… Expand Background: Survivin, a member of the apoptosis protein inhibitor family, is an essential regulator of cell division and a… Expand Relapse of drug-resistant acute lymphoblastic leukemia (ALL) has been associated with increased expression of survivin/BIRC5, an… Expand Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL
Background : Survivin, the smallest member of the… Expand A th W T l h 1 A it P t ik 1 K i k P P d l 1 J A 1 F i M L ki 2 K R ï 2 St K l b k † Ab B hbi d 3* Poster A216 n ony . o c er, m… Expand Survivin plays an important role in preventing apoptosis and permitting mitosis, and is highly expressed in various human cancers… Expand 1) EZN-3042 displayed potent in vitro knockdown of survivin mRNA and growth inhibition of several human cancer cell lines (IC50… Expand