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EX 527

Known as: EX-527, EX527 cpd 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
SIRT1 Mediates Septic Cardiomyopathy in a Murine Model of Polymicrobial Sepsis.
BACKGROUND Cardiac dysfunction, a common complication from severe sepsis, is associated with increased morbidity and mortality… 
2020
2020
Exendin‐4 exhibits a tumour suppressor effect in SKOVR‐3 and OVACR‐3 ovarian cancer cells lines by the activation of SIRT1 and inhibition of NF‐κB
This study investigated if EX‐527 has an anti‐tumour effect in SKOV‐3 and OVCAR‐3 ovarian cancer (OC) cell lines and if this… 
2019
2019
MicroRNA‐506 upregulation contributes to sirtuin 1 inhibition of osteoclastogenesis in bone marrow stromal cells induced by TNF‐α treatment
As a deacetylase relying on NAD, sirtuin 1 (SIRT1) has been proven to inhibit osteoclastogenesis directly by repressing reactive… 
2018
2018
[Polydatin inhibits cell proliferation and expressions of inflammatory cytokines in THP-1 cells induced by ox-LDL via up-regulating SIRT1].
Objective To investigate the effects of polydatin on cell proliferation and cytokine expression in THP-1 monocyte-derived… 
2017
2017
Abstract 5: The effects of SIRT1 inhibitors nicotinamide and Ex-527 on lymphoma cells
SIRT1 is a well-known lysine-deacetylase, having both histone and non-histone proteins as molecular targets. SIRT1 may function… 
2015
2015
Galectin-9 in Combination With EX-527 Prolongs the Survival of Cardiac Allografts in Mice After Cardiac Transplantation.
2014
2014
D-galactosamine/lipopolysaccharide-induced hepatotoxicity downregulates sirtuin 1 in rat liver: role of sirtuin 1 modulation in hepatoprotection.
D-Galactosamine/Lipopolysaccharide (D-GalN/LPS) is a well known model of hepatotoxicity that closely resembles acute liver… 
2014
2014
Regulation of (pro)renin receptor expression in mIMCD via the GSK-3β-NFAT5-SIRT-1 signaling pathway.
The localization and regulation of (pro)renin receptor (PRR) expression in kidney collecting duct cells are not well established… 
2014
2014
Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis
BACKGROUND We have recently demonstrated that inhibition of histone deacetylase (HDAC) Class I, II, and IV with nonspecific HDAC… 
2011
2011
Measurement of the cellular deacetylase activity of SIRT1 on p53 via LanthaScreen® technology.
Upon genomic insult, the tumor suppressor p53 is phosphorylated and acetylated at specific serine and lysine residues, increasing… 
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