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EPZ015666

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Clinical trials directed at mechanistic target of rapamycin (mTOR) inhibition have yielded disappointing results in glioblastoma… Expand
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2019
2019
TNBC is a highly heterogeneous and aggressive breast cancer subtype associated with high relapse rates, and for which no targeted… Expand
2018
2018
Arginine methyltransferases critically regulate cellular homeostasis by modulating the functional outcome of their substrates… Expand
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2017
2017
To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and… Expand
2017
2017
Protein arginine methyltransferase 5 (PRMT5) is an arginine methylation methyltransferase that regulates various physiological… Expand
2017
2017
Pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) are notoriously challenging for treatment. Hyperactive… Expand
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2017
2017
The protein arginine methyltransferase (PRMT) family of enzymes comprises nine family members in mammals. They catalyze arginine… Expand
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Highly Cited
2016
Highly Cited
2016
The recent publication of a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) provides the scientific… Expand
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2016
2016
Abstract 1. Metabolite profiling and identification studies were conducted to understand the cross-species differences in the… Expand
Highly Cited
2015
Highly Cited
2015
Protein arginine methyltransferase-5 (PRMT5) is reported to have a role in diverse cellular processes, including tumorigenesis… Expand
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