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Clinical trials directed at mechanistic target of rapamycin (mTOR) inhibition have yielded disappointing results in glioblastoma… Expand TNBC is a highly heterogeneous and aggressive breast cancer subtype associated with high relapse rates, and for which no targeted… Expand Arginine methyltransferases critically regulate cellular homeostasis by modulating the functional outcome of their substrates… Expand To probe the role of protein arginine methyltransferase 5 (PRMT5) in regulating inflammation, cell proliferation, migration and… Expand Protein arginine methyltransferase 5 (PRMT5) is an arginine methylation methyltransferase that regulates various physiological… Expand Pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) are notoriously challenging for treatment. Hyperactive… Expand The protein arginine methyltransferase (PRMT) family of enzymes comprises nine family members in mammals. They catalyze arginine… Expand The recent publication of a potent and selective inhibitor of protein methyltransferase 5 (PRMT5) provides the scientific… Expand Abstract 1. Metabolite profiling and identification studies were conducted to understand the cross-species differences in the… Expand Protein arginine methyltransferase-5 (PRMT5) is reported to have a role in diverse cellular processes, including tumorigenesis… Expand