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EPZ-5676
Known as:
DOT1L Inhibitor EPZ-5676
A small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676…
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National Institutes of Health
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Related topics
Related topics
1 relation
Broader (1)
Benzimidazoles
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
COMBINING DOT1L INHIBITOR EPZ-5676 WITH SORAFENIB TO TREAT MLL-REARRANGED (MLL-R) PEDIATRIC ACUTE MYELOID LEUKEAMIA (AML)
A. Lonetti
,
R. Masetti
,
+6 authors
A. Pession
2016
Corpus ID: 181966796
Review
2016
Review
2016
Design , Synthesis and Characterization of Small Molecules Targeting MLL 1 Methyltransferase in Mixed-Lineage Leukemia
Ting‐Rong Chern
2016
Corpus ID: 3928912
The rearrangements of the MLL located on the chromosome 11q23 are the major cause of mixed-lineage leukemia. The translocation…
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2015
2015
Abstract 2701: Characterization of acquired EPZ-5676 resistance in cell line models of MLL rearranged leukemia
S. Daigle
,
Carly Campbell
,
+5 authors
Jesse J. Smith
2015
Corpus ID: 78594204
DOT1L inhibitor EPZ-5676 is currently under Phase 1 clinical trial investigation in relapsed/refractory patients with acute…
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