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EPZ-5676

Known as: DOT1L Inhibitor EPZ-5676 
A small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676… Expand
National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
Pinometostat (EPZ-5676) is a first-in-class small-molecule inhibitor of the histone methyltransferase disrupter of telomeric… Expand
2017
2017
DOT1L is a protein methyltransferase involved in the development and maintenance of MLL-rearranged (MLL-r) leukemia through its… Expand
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2016
2016
Introduction: MLL-rearranged (MLL-r) acute leukemia in children is characterized by young age at presentation and a poor overall… Expand
2015
2015
Introduction: Aberrant fusion proteins involving the MLL histone methyltransferase (HMT) result in recruitment of another HMT… Expand
2015
2015
AbstractPurpose The metabolism and disposition of the first-in-class DOT1L inhibitor, EPZ-5676 (pinometostat), was investigated… Expand
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2015
2015
Protein methyltransferases are emerging as promising drug targets for therapeutic intervention in human cancers. Pinometostat… Expand
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Highly Cited
2014
Highly Cited
2014
EPZ-5676 [(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl… Expand
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Highly Cited
2014
Highly Cited
2014
(2R,3R,4S,5R)‐2‐(6‐Amino‐9H‐purin‐9‐yl)‐5‐((((1r,3S)‐3‐(2‐(5‐(tert‐butyl)‐1H‐benzo[d]imidazol‐2‐yl)ethyl)cyclobutyl)(isopropyl… Expand
2014
2014
Introduction: Rearrangements of the MLL (mixed lineage leukemia) gene on chromosome 11q23 are present in 5-10% of either acute… Expand
Highly Cited
2013
Highly Cited
2013
Rearrangements of the MLL gene define a genetically distinct subset of acute leukemias with poor prognosis. Current treatment… Expand
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