EPZ-5676

Known as: DOT1L Inhibitor EPZ-5676 
A small molecule inhibitor of histone methyltransferase with potential antineoplastic activity. Upon intravenous administration, EPZ-5676… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2013-2017
024620132017

Papers overview

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2017
2017
DOT1L is a protein methyltransferase involved in the development and maintenance of MLL-rearranged (MLL-r) leukemia through its… (More)
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2017
2017
OBJECTIVE To investigate the synergistic antiproliferative and inducing-apoptotic effect of EPZ-5676 combined with… (More)
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Review
2017
Review
2017
Acute leukemias bearing mixed lineage leukemia (MLL) rearrangements are aggressive diseases characterized by a poor overall… (More)
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Review
2016
Review
2016
Leukemia carring translocation at the 11q23 locus is referred to MLL-rearranged (MLL-r) leukemia, and the occurrence of this… (More)
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2015
2015
The metabolism and disposition of the first-in-class DOT1L inhibitor, EPZ-5676 (pinometostat), was investigated in rat and dog… (More)
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2015
2015
Protein methyltransferases are emerging as promising drug targets for therapeutic intervention in human cancers. Pinometostat… (More)
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2015
2015
Genetic alterations of the mixed-lineage leukemia (MLL) gene are commonly implicated in the development of acute leukemias. In… (More)
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2014
2014
(2R,3R,4S,5R)-2-(6-Amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl… (More)
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2014
2014
EPZ-5676 [(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl… (More)
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Highly Cited
2013
Highly Cited
2013
Rearrangements of the MLL gene define a genetically distinct subset of acute leukemias with poor prognosis. Current treatment… (More)
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