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EMD 55900

Known as: EMD 55 900, Mab 425 
A murine monoclonal antibody targeting the epidermal growth factor receptor (EGFR) exhibiting anti-tumor activity. EMD 55900 antibody binds to the… 
National Institutes of Health

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antigen binding

Papers overview

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Highly Cited
2009
Highly Cited
2009
A novel mechanism for anti‐EGFR antibody action involves chemokine‐mediated leukocyte infiltration
Overexpression of the epidermal growth factor receptor (EGFR) is a hallmark of squamous cell carcinoma of the head and neck… 
2004
2004
Dose-dependent access of murine anti-epidermal growth factor receptor monoclonal antibody to tumor cells in patients with advanced laryngeal and hypopharyngeal carcinoma
The murine IgG2a monoclonal antibody (mAb) EMD 55900 was produced against the human epidermoid carcinoma cell line A431, with… 
2002
2002
Antitumor effect of MAb EMD 55900 depends on EGF-R expression and histopathology.
The proliferative stimulus of the epidermal growth factor (EGF) in human epithelial cells is mediated by its binding to the… 
2002
2002
Anti‐epidermal growth factor receptor‐antibody therapy for treatment of breast cancer
Recent studies demonstrated that tumors overexpressing the epidermal growth factor receptor (EGF‐R, erbB‐1) are associated with… 
2001
2001
Tumor necrosis factor alpha sensitizes low epidermal growth factor receptor (EGFR)-expressing carcinomas for anti-EGFR therapy.
Analysis of 1,060 xenotransplants derived from cancer cell lines as wel as spontaneously occurring tumors from the larynx… 
2001
2001
Tumor Necrosis Factor a Sensitizes Low Epidermal Growth Factor Receptor ( EGFR )-expressing Carcinomas for Anti-EGFR Therapy 1
Analysis of 1060 xenotransplants derived from cancer cell lines as well as spontaneously occurring tumors from the larynx… 
1997
1997
Growth inhibition of human papillary thyroid carcinoma cells and multicellular spheroids by anti-EGF-receptor antibody.
EGF has been reported to stimulate thyroid cell proliferation. In the present study we investigated the effects of anti-EGF-R… 
1995
1995
The epidermal growth factor receptor in glioblastoma: genomic amplification, protein expression, and patient survival data in a therapeutic trial.
Human glioblastomas were evaluated for overexpression of the epidermal growth factor receptor (EGFR) in a therapeutic trial with… 
1994
1994
Improved uptake of 125i-mab 425 into high grade glioma cells by pretreatment with chloroquine and/or unlabeled mouse IGG: Possible therapeutic applications
1993
1993
Finite proliferative lifespanin vitro of a human breast cancer cell strain isolated from a metastatic lymph node
SummaryWe recently described culture conditions that allow proliferation of metastatic human breast cancer cells from biopsy… 
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