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EMD 521873

Known as: EMD 521873 immunocytokine, immunocytokine EMD 521873 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Immunocytokine NHS-IL2-LTRecombinant Fusion Proteins

Narrower (1)

Selectikine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The immunocytokine L19-IL2: An interplay between radiotherapy and long-lasting systemic anti-tumour immune responses
ABSTRACT Recently, we have shown that the administration of the tumour-targeted antibody-based immunocytokine L19-IL2 after… 
2015
2015
Combination of radiotherapy with the immunocytokine L19-IL2: Additive effect in a NK cell dependent tumour model.
Highly Cited
2013
Highly Cited
2013
Antibody-Based Delivery of Interleukin-2 to Neovasculature Has Potent Activity Against Acute Myeloid Leukemia
Neovascular structures in acute myeloid leukemia can be targeted using a cognate antibody fused to human interleukin-2. The Blood… 
Highly Cited
2013
Highly Cited
2013
The antibody-based targeted delivery of TNF in combination with doxorubicin eradicates sarcomas in mice and confers protective immunity
Background:Soft-tissue sarcomas are a group of malignancies of mesenchymal origin, which typically have a dismal prognosis if… 
Highly Cited
2011
Highly Cited
2011
A Dose-Escalation and Signal-Generating Study of the Immunocytokine L19-IL2 in Combination with Dacarbazine for the Therapy of Patients with Metastatic Melanoma
Purpose: L19-IL2 is an immunocytokine composed of an antibody fragment specific to the EDB domain of fibronectin, a tumor… 
2010
2010
Expression, engineering and characterization of the tumor-targeting heterodimeric immunocytokine F8-IL12.
Proinflammatory cytokines have been used for several years in patients with advanced cancer but their administration is typically… 
Highly Cited
2010
Highly Cited
2010
Combination of temozolomide with immunocytokine F16–IL2 for the treatment of glioblastoma
Background:Glioblastoma patients are still not cured by the treatments available at the moment. We investigated the therapeutic… 
Highly Cited
2010
Highly Cited
2010
The immunocytokine F8-IL2 improves the therapeutic performance of sunitinib in a mouse model of renal cell carcinoma.
Highly Cited
2008
Highly Cited
2008
The Targeted Immunocytokine L19-IL2 Efficiently Inhibits the Growth of Orthotopic Pancreatic Cancer
Purpose: Effective control of pancreatic cancer has been hampered primarily by the lack of tumor specificity of current treatment… 
Highly Cited
2004
Highly Cited
2004
Safety, Pharmacokinetics, and Biological Pharmacodynamics of the Immunocytokine EMD 273066 (huKS-IL2): Results of a Phase I Trial in Patients with Prostate Cancer
Abstract: This phase 1 clinical trial was conducted to evaluate the safety and to determine the maximum tolerated dose (MTD) of… 
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