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EM-1745

National Institutes of Health

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2 relations

Broader (1)

Estradiol
analogs & derivatives

Papers overview

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Highly Cited
2009
Highly Cited
2009
Binary and ternary crystal structure analyses of a novel inhibitor with 17beta-HSD type 1: a lead compound for breast cancer therapy.
Oestradiol is a well-characterized sex hormone that stimulates breast cancer and other oestrogen-related diseases. 17beta… 
2009
2009
Improved synthesis of EM-1745, preparation of its C17-ketone analogue and comparison of their inhibitory potency on 17β-hydroxysteroid dehydrogenase type 1
Endocrine therapies are widely used for the treatment of estrogen-sensitive diseases. 17β-hydroxysteroid dehydrogenase type 1 (17… 
Review
2008
Review
2008
Design and synthesis of bisubstrate inhibitors of type 1 17beta-hydroxysteroid dehydrogenase: overview and perspectives.
Highly Cited
2004
Highly Cited
2004
Synthesis of simplified hybrid inhibitors of type 1 17beta-hydroxysteroid dehydrogenase via cross-metathesis and sonogashira coupling Reactions.
[structure: see text] The inhibitor of type 1 17beta-hydroxysteroid dehydrogenase EM-1745 (1) exhibits affinity for both the… 
Highly Cited
2002
Highly Cited
2002
A concerted, rational design of type 1 17β‐hydroxysteroid dehydrogenase inhibitors: estradiol‐adenosine hybrids with high affinity
Human estrogenic 17β‐hydroxysteroid dehydrogenase (17β‐HSD type 1) catalyzes the final step in the synthesis of active estrogens… 
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