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National Institutes of Health
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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3…
Danielle L. Aubele
Journal of medicinal chemistry
Corpus ID: 207231000
Herein, we describe our strategy to design metabolically stable γ-secretase inhibitors which are selective for inhibition of A…
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