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EKB 569

Known as: EKB-569, EKI-569, (2E)-N-(4-((3-Chloro-4-fluorophenyl)amino)-3-cyano-7-ethoxyquinolin-6-yl)-4-(dimethylamino)but-2-enamide 
A 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. EKB-569 irreversibly binds covalently to epidermal… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AminoquinolinesAniline Compounds

Narrower (1)

pelitinib

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Novel EGFR-TK Inhibitor EKB-569 Inhibits Hepatocellular Carcinoma Cell Proliferation by AKT and MAPK Pathways
Epidermal growth factor receptor (EGFR)-targeted therapies have been effective in some cancers, but not in hepatocellular… 
2011
2011
Irreversible EGFR Inhibitor EKB-569 Targets Low-LET γ-Radiation-Triggered Rel Orchestration and Potentiates Cell Death in Squamous Cell Carcinoma
EKB-569 (Pelitinib), an irreversible EGFR tyrosine kinase inhibitor has shown potential therapeutic efficiency in solid tumors… 
2008
2008
A Phase I Study of EKB-569 in Combination with Capecitabine in Patients with Advanced Colorectal Cancer
Purpose: To determine the maximum tolerated dose (MTD), characterize the principal toxicities, and assess the pharmacokinetics of… 
2007
2007
In-Cell Western analysis of Helicobacter pylori-induced phosphorylation of extracellular-signal related kinase via the transactivation of the epidermal growth factor receptor.
2005
2005
Rasterelektronenmikroskopische Untersuchungen an Samen der GattungAllium L. II
ZusammenfassungDie Testa-Epidermisskulpturen von Arten der GattungAllium L. wurden rasterelektronenmikroskopisch untersucht.Dabei… 
2004
2004
Phase 1/2a study of EKB-569, an irreversible inhibitor of epidermal growth factor receptor, in combination with 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX-4) in patients with advanced…
3579 Background: EKB-569 is an orally active, low molecular weight, selective, irreversible inhibitor of the epidermal growth… 
Highly Cited
2004
Highly Cited
2004
Epidermal growth factor receptor tyrosine kinase inhibition is not protective in PCK rats.
BACKGROUND Advances in the understanding of cystogenesis, identification of the PKHD1 gene and availability of a rat model (the… 
2004
2004
Phosphorylation of extracellular signal-regulated kinase 1 and 2, protein kinase B, and signal transducer and activator of transcription 3 are differently inhibited by an epidermal growth factor…
EKB-569 is an irreversible inhibitor of epidermal growth factor receptor (EGF-R) tyrosine kinase. It inhibits EGF-induced… 
Review
2003
Review
2003
Clinical studies with non-iressa EGFR tyrosine kinase inhibitors.
1991
1991
Structural basis of specific and efficient phosphorylation of peptides derived from p34cdc2 by a pp60src-related protein tyrosine kinase.
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