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EFTUD2 gene
Known as:
U5-116KD
, elongation factor Tu GTP binding domain containing 2
, ELONGATION FACTOR Tu GTP-BINDING DOMAIN-CONTAINING 2
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage
Z. Lv
,
Zhihong Wang
,
+13 authors
Guojiang Chen
Mucosal Immunology
2019
Corpus ID: 195804312
Alternative splicing (AS) of mRNA is known to be involved in regulation of immune cell differentiation and activation. Elongation…
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2017
2017
Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors
Lei Lei
,
Shouyu Yan
,
+8 authors
Jing Xiong
Nucleic acids research
2017
Corpus ID: 19034314
Abstract Haploinsufficiency of EFTUD2 (Elongation Factor Tu GTP Binding Domain Containing 2) is linked to human mandibulofacial…
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Highly Cited
2016
Highly Cited
2016
CryoEM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution
Thi Hoang Duong Nguyen
,
W. P. Galej
,
+4 authors
K. Nagai
Nature
2016
Corpus ID: 4470107
U4/U6.U5 tri-snRNP represents a substantial part of the spliceosome before activation. A cryo-electron microscopy structure of…
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2016
2016
Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.
M. Mayerle
,
C. Guthrie
RNA
2016
Corpus ID: 3156690
Pre-mRNA splicing must occur with high fidelity and efficiency for proper gene expression. The spliceosome uses DExD/H box…
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2015
2015
Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells
Naoki Sato
,
Masao Maeda
,
+8 authors
T. Senga
Cancer medicine
2015
Corpus ID: 9180906
RNA splicing is a fundamental process for protein synthesis. Recent studies have reported that drugs that inhibit splicing have…
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Highly Cited
2009
Highly Cited
2009
Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2
Lingdi Zhang
,
Tao Xu
,
+6 authors
R. Zhao
Nature Structural &Molecular Biology
2009
Corpus ID: 9741517
Brr2 is a DExD/H-box helicase responsible for U4/U6 unwinding during spliceosomal activation. Brr2 contains two helicase-like…
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2009
2009
Analysis of Synthetic Lethality Reveals Genetic Interactions Between the GTPase Snu114p and snRNAs in the Catalytic Core of the Saccharomyces cerevisiae Spliceosome
L. Frazer
,
S. Lovell
,
R. O’Keefe
Genetics
2009
Corpus ID: 32128137
Conformational changes of snRNAs in the spliceosome required for pre-mRNA splicing are regulated by eight ATPases and one GTPase…
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Highly Cited
2008
Highly Cited
2008
CLO/GFA1 and ATO are novel regulators of gametic cell fate in plants.
C. Moll
,
Ludwig von Lyncker
,
+5 authors
R. Groß-Hardt
The Plant journal : for cell and molecular…
2008
Corpus ID: 40845089
The formation of gametes is a key step in the life cycle of any sexually reproducing organism. In flowering plants, gametes…
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2006
2006
Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain.
T. Brenner
,
C. Guthrie
RNA
2006
Corpus ID: 25524771
Snu114 is a U5 snRNP protein essential for pre-mRNA splicing. Based on its homology with the ribosomal translocase EF-G, it is…
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Highly Cited
2005
Highly Cited
2005
Genetic Analysis Reveals a Role for the C Terminus of the Saccharomyces cerevisiae GTPase Snu114 During Spliceosome Activation
T. Brenner
,
C. Guthrie
Genetics
2005
Corpus ID: 6295782
Snu114 is the only GTPase required for mRNA splicing. As a homolog of elongation factor G, it contains three domains (III–V…
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