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EFTUD2 gene

Known as: U5-116KD, elongation factor Tu GTP binding domain containing 2, ELONGATION FACTOR Tu GTP-BINDING DOMAIN-CONTAINING 2 
National Institutes of Health

Papers overview

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2019
2019
Spliceosome protein Eftud2 promotes colitis-associated tumorigenesis by modulating inflammatory response of macrophage
Alternative splicing (AS) of mRNA is known to be involved in regulation of immune cell differentiation and activation. Elongation… 
2017
2017
Spliceosomal protein eftud2 mutation leads to p53-dependent apoptosis in zebrafish neural progenitors
Abstract Haploinsufficiency of EFTUD2 (Elongation Factor Tu GTP Binding Domain Containing 2) is linked to human mandibulofacial… 
Highly Cited
2016
Highly Cited
2016
CryoEM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolution
U4/U6.U5 tri-snRNP represents a substantial part of the spliceosome before activation. A cryo-electron microscopy structure of… 
2016
2016
Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing.
Pre-mRNA splicing must occur with high fidelity and efficiency for proper gene expression. The spliceosome uses DExD/H box… 
2015
2015
Inhibition of SNW1 association with spliceosomal proteins promotes apoptosis in breast cancer cells
RNA splicing is a fundamental process for protein synthesis. Recent studies have reported that drugs that inhibit splicing have… 
Highly Cited
2009
Highly Cited
2009
Structural evidence for consecutive Hel308-like modules in the spliceosomal ATPase Brr2
Brr2 is a DExD/H-box helicase responsible for U4/U6 unwinding during spliceosomal activation. Brr2 contains two helicase-like… 
2009
2009
Analysis of Synthetic Lethality Reveals Genetic Interactions Between the GTPase Snu114p and snRNAs in the Catalytic Core of the Saccharomyces cerevisiae Spliceosome
Conformational changes of snRNAs in the spliceosome required for pre-mRNA splicing are regulated by eight ATPases and one GTPase… 
Highly Cited
2008
Highly Cited
2008
CLO/GFA1 and ATO are novel regulators of gametic cell fate in plants.
The formation of gametes is a key step in the life cycle of any sexually reproducing organism. In flowering plants, gametes… 
2006
2006
Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domain.
Snu114 is a U5 snRNP protein essential for pre-mRNA splicing. Based on its homology with the ribosomal translocase EF-G, it is… 
Highly Cited
2005
Highly Cited
2005
Genetic Analysis Reveals a Role for the C Terminus of the Saccharomyces cerevisiae GTPase Snu114 During Spliceosome Activation
Snu114 is the only GTPase required for mRNA splicing. As a homolog of elongation factor G, it contains three domains (III–V… 
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