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E 643

Known as: E-643, E643 
National Institutes of Health

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bunazosinbunazosin hydrochloride

Papers overview

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2004
2004
Antihypertensive effect of E-643, a new alpha-adrenergic blocking agent
SummaryTo determine whether E-643, a new α-blocking agent, would reduce the blood pressure, regardless of the posture, a 1 mg… 
1986
1986
Acute systemic and regional hemodynamic effects of alpha 1-adrenoceptor blockade in conscious spontaneously hypertensive rats.
The acute hemodynamic effect of the selective alpha1-antagonist, 2-[4-(n-butyryl)-homopiperazine-1-y1]-4-amino-6,7-dimethoxy… 
1985
1985
[Effects of new antihypertensive agent, 2-[4-(n-butyryl)-homopiperazine-1-ul]-4-amino-6, 7-dimethoxy-quinazoline (E-643), on blood pressure, urinary sodium excretion and urinary norepinephrine…
Present study was undertaken to elucidate the effects of E-643, on blood pressure, urinary electrolyte (U-Na, U-K) and… 
1982
1982
Characteristics of [3H]E-643-binding to alpha adrenoceptors.
Radiolabeled E-643, a newly developed antihypertensive compound, bound specifically to a preparation obtained from rat brain with… 
Highly Cited
1981
Highly Cited
1981
Comparison of pre- and postsynaptic alpha-adrenoceptor blocking effects of E-643 in the isolated vas deferens of the rat.
Effectiveness of E-643, a newly developed alpha-blocker, and four alpha-antagonists in blocking pre- and postsynaptic alpha… 
1981
1981
Chronotropic and inotropic effects of 3 kinds of alpha-adrenergic blockers on the isolated dog atria.
Using the isolated and blood-perfused dog atrial preparation, chronotropic and inotropic responses to 3 kinds of alpha-adrenergic… 
1980
1980
alpha-Adrenoceptor blocking properties of a new antihypertensive agent, 2-[4-(n-butyryl)-homopiperazine-1-yl]-4-amino-6,7-dimethoxyquinazoline (E-643).
Postsynaptic alpha-receptor blocking properties of E-643 were studied in vivo and in vitro and compared with these same… 
1980
1980
Effects of alpha blockers on blood pressure and on the Ca-contracture of cat aortic strips.
To further clarify the hypotensive mechanism of adrenergic alpha blockers, effects of several alpha blockers on systemic blood… 
1980
1980
The potentiating effect of an alpha-adrenergic blocking agent (E-643) on the action of bronchodilators.
The effect of 2-[N-(n-butyloyl)homopiperazin-N'-yl]-4-amino-6,7-dimethoxy quinazoline hydrochloride (E-643), a new alpha… 
1977
1977
Antihypertensive effect of combined treatment with alpha- and beta-adrenergic blockers in the spontaneously hypertensive rat.
Using a continuous systolic monitor, effects of oral administration of three alpha-adrenergic blockers, i.e. phenoxybenzamine… 
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