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E 6123

Known as: 4H-Pyrido(4',3':4,5)thieno(3,2-f)(1,2,4)triazolol(4,3-a)(1,4)diazepine, 6-(2-chlorophenyl)-9-(cyclopropylcarbonyl)-7,8,9,10-tetrahydro-1,4-dimethyl-, (S)-, E-6123 
National Institutes of Health

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2 relations

Broader (2)

AzepinesTriazoles

Papers overview

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2001
2001
PAF mediates cigarette smoke-induced goblet cell metaplasia in guinea pig airways.
Goblet cell metaplasia is an important morphological feature in the airways of patients with chronic airway diseases; however… 
2000
2000
[The role of lipid mediators in bronchial hyperresponsiveness and airway eosinophil accumulation induced by antigen challenge in guinea pigs].
The aim of this study was elucidate the role of lipid mediators in bronchial hyperresponsiveness (BHR) and airway eosinophil… 
1995
1995
PAF ANTAGONISTS BLOCK INDUCTION OF NITRIC OXIDE SYNTHASE IN CULTURED MACROPHAGES AND VASCULAR SMOOTH MUSCLE CELLS
1. Nitric oxide (NO) synthase inhibitors and Paf antagonists abrogate hypotension in septic shock. The latter may act by blocking… 
1994
1994
Effect of PAF-antagonists on aeroallergen-induced bronchial eosinophilia in guinea pigs: a therapeutic approach.
Aeroallergen-induced eosinophilia in actively sensitized guinea pigs was used as a marker of bronchial inflammation in this study… 
1994
1994
Dual effects of a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing enzymes in beagle dog.
1. We have examined the effects of (S)-(+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl-8, 11-dimethyl-2,3,4,5-tetrahydro-8H-pyrido… 
1991
1991
Activity of a novel thienodiazepine derivative as a platelet-activating factor antagonist in guinea pig lungs. Effects on platelet-activating factor and allergen induced eosinophil accumulation.
Platelet-activating factor (PAF) inhalation in guinea pigs caused a significant increase in the number of eosinophils recovered… 
1991
1991
Pharmacological activities of a novel thienodiazepine derivative as a platelet-activating factor antagonist. Effects on microvascular permeability, hypotension and nephrosis.
The effects of a newly synthesized platelet-activating factor (PAF) antagonist, (S)-(+)-6-(2-chlorophenyl)-3-cyclopropanecarbonyl… 
1990
1990
Pharmacological activities of a novel thienodiazepine derivative as a platelet-activating factor antagonist.
(S)-(+)-6-(2-Chlorophenyl)-3-cyclopropanecarbonyl-8,11- dimethyl - 2,3,4,5 - tetrahydro - 8H - pyrido[4',3':4,5] thieno[3,2-fl-[1… 
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