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E-6087

National Institutes of Health

Papers overview

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2010
2010
Cyclooxygenase-independent inhibitory effects on T cell activation of novel 4,5-dihydro-3 trifluoromethyl pyrazole cyclooxygenase-2 inhibitors.
2009
2009
COX-2 Inhibition Combined with Radiation Reduces Orthotopic Glioma Outgrowth by Targeting the Tumor Vasculature.
Cyclooxygenase 2 (COX-2) inhibitors have been shown to enhance tumor's response to radiation in several animal models. The strong… 
2004
2004
Enantioselective HPLC determination of E-6087, a new COX-2 inhibitor, in human plasma: Validation and pharmacokinetic application.
E-6087 is a nonsteroidal anti-inflammatory compound that selectively inhibits cyclooxygenase-2. Because E-6087 has a chiral… 
2002
2002
Enantioseparation of novel COX‐2 anti‐ inflammatory drugs by capillary electrophoresis using single and dual cyclodextrin systems
A capillary electrophoresis method was developed for the enantioseparation of three novel cyclooxygenase‐2 (COX‐2) inhibitor… 
2001
2001
Pharmacokinetics of E‐6087, a new anti‐inflammatory agent, in rats and dogs
The pharmacokinetics of E‐6087, a newly developed cyclooxygenase‐2 inhibitor, was studied in rats and dogs after single oral and… 
2001
2001
Development and validation of two chromatographic methods for the quantification of E-6087 and one of its metabolites, E-6132, in rat plasma.
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