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E-55888

 
National Institutes of Health

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Topic mentions per year

2009-2014
0120092014

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2015
2015
Labeling and preliminary in vivo evaluation of the 5-HT(7) receptor selective agonist [(11)C]E-55888.
E-55888 has been identified as a selective serotonin 7 (5-HT7) receptor agonist. In this study, we describe the synthesis… (More)
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Review
2014
Review
2014
Selective agonists for serotonin 7 (5-HT7) receptor and their applications in preclinical models: an overview.
The serotonin 7 (5-HT7) receptor was the last serotonin receptor subtype to be discovered in 1993. This receptor system has been… (More)
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2012
2012
GABA, but not opioids, mediates the anti-hyperalgesic effects of 5-HT7 receptor activation in rats suffering from neuropathic pain.
Among receptors mediating serotonin actions in pain control, the 5-HT(7)R is of special interest because it is expressed by… (More)
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2012
2012
Assessment of 5-HT7 Receptor Agonists Selectivity Using Nociceptive and Thermoregulation Tests in Knockout versus Wild-Type Mice
No study has ever examined the effect of 5-HT(7) receptor agonists on nociception by using 5-HT(7) receptor knockout mice. Basal… (More)
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2011
2011
Potentiation of morphine analgesia by adjuvant activation of 5-HT7 receptors.
Spinal blockade of 5-HT7 receptors has been reported to inhibit the antinociceptive effect of opioids. In this study, we found… (More)
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2009
2009
5-HT7 receptor activation inhibits mechanical hypersensitivity secondary to capsaicin sensitization in mice.
This work aimed to evaluate the potential role of the 5-HT(7) receptor in nociception secondary to a sensitizing stimulus in mice… (More)
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