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Dose-dependent

Refers to the effects of treatment with a drug. If the effects change when the dose of the drug is changed, the effects are said to be dose-dependent… 
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Nanoparticles, free radicals and oxidative stress
Summary Free radicals are unstable atoms or molecules with free outer electrons. This makes them highly reactive because free… 
Highly Cited
2009
Highly Cited
2009
Protective effect of tea polyphenols against paracetamol-induced hepatotoxicity in mice is significantly correlated with cytochrome P450 suppression.
AIM To investigate the hepatoprotective activity of tea polyphenols (TP) and its relation with cytochrome P450 (CYP450… 
2005
2005
Peritransplant treatment with cobalt protoporphyrin attenuates chronic renal allograft rejection
Allogen‐independent injury contributes to chronic rejection in renal allografts and heme oxygenase‐1 (HO‐1) has been shown to be… 
Highly Cited
2001
Highly Cited
2001
Marked antitumor activity of a new potent acronycine derivative in orthotopic models of human solid tumors.
S 23906-1 is a novel acronycine derivative selected on the basis of its potency in vitro. We investigated the antitumor activity… 
Highly Cited
1996
Highly Cited
1996
Cardiovascular and pulmonary effects of sevoflurane anesthesia in horses.
The effects of 1.0, 1.5, and 2.0 minimum alveolar concentration (MAC) of sevoflurane on hemodynamic, pulmonary and blood… 
1988
1988
Role of hypovolemic hemoconcentration in dose-dependent flow decline observed in murine tumors after intraperitoneal administration of glucose or mannitol.
Responses of tumor microcirculation (RBC flux) to i.p. glucose or mannitol injections were studied in early generation… 
Highly Cited
1985
Highly Cited
1985
Effect of a stable prostacyclin analogue on platelet function and experimentally-induced thrombosis in the microcirculation.
Sodium dl-4-[1R,2R,3aS,8bS)-1,2,3a,8b-tetrahydro- 2-hydroxy-1-[(3S,4RS)-3-hydroxy-4-methyl-oct-6- yne-(E)-1-enyl]-5-cyclopenta[b… 
1984
1984
THE EFFECT OF DONOR‐SPECIFIC TRANSFUSIONS ON RAT HEART ALLOGRAFT SURVIVAL
A rat heart allograft model employing donor-specific transfusions (DSTs) was used to investigate several questions relevant to… 
1978
1978
Complement-dependent stimulation of normal lymphocytes by immune complexes.
Normal rabbit lymphocytes were stimulated to proliferate in vitro by antibody-antigen complexes. Stimulation was dependent upon C… 
Highly Cited
1973
Highly Cited
1973
IMMUNOLOGICAL TOLERANCE TO A HAPTEN
Treatment of mice with a nonimmunogenic preparation of free reactive hapten, trinitrobenzene sulfonic acid (TNBS), leads to the… 
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