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Dose-dependent

Refers to the effects of treatment with a drug. If the effects change when the dose of the drug is changed, the effects are said to be dose-dependent… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Strong evidence indicates that reduction of salt intake lowers blood pressure and reduces the risk of cardiovascular disease (CVD… Expand
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Highly Cited
2013
Highly Cited
2013
BACKGROUND The stability and propagation of hepatitis C virus (HCV) is dependent on a functional interaction between the HCV… Expand
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Highly Cited
2006
Highly Cited
2006
RNA interference (RNAi) is a universal and evolutionarily conserved phenomenon of post-transcriptional gene silencing by means of… Expand
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Highly Cited
2004
Highly Cited
2004
The safety and bone antiresorptive effect of a single subcutaneous dose of AMG 162, a human monoclonal antibody to RANKL, was… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE This study evaluated the ability of the incretin mimetic exenatide (exendin-4) to improve glycemic control in patients… Expand
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Highly Cited
2003
Highly Cited
2003
The Oct-3/4 transcription factor sustains embryonic stem (ES) cell self-renewal and is a dose-dependent cell fate determinant. In… Expand
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Highly Cited
2002
Highly Cited
2002
During bone formation and fracture healing there is a cross-talk between endothelial cells and osteoblasts. We previously showed… Expand
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Highly Cited
1997
Highly Cited
1997
Recent data have identified leptin as an afferent signal in a negative-feedback loop regulating the mass of the adipose tissue… Expand
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Highly Cited
1994
Highly Cited
1994
Objectives: To evaluate the safety, pharmacokinetics, and efficacy of human recombinant interleukin‐1 receptor antagonist (IL‐lra… Expand
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Highly Cited
1987
Highly Cited
1987
We administered recombinant human erythropoietin to 25 anemic patients with end-stage renal disease who were undergoing… Expand
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