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Direct Thrombin Inhibitor [EPC]

Known as: Direct Thrombin Inhibitor 
 
National Institutes of Health

Papers overview

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Review
2014
Review
2014
The acute management of haemorrhage, surgery and overdose in patients receiving dabigatran
Dabigatran is an oral direct thrombin inhibitor (DTI) licensed for stroke prevention in atrial fibrillation and likely to be soon… Expand
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2012
2012
Plasma-diluted thrombin time to measure dabigatran concentrations during dabigatran etexilate therapy.
New anticoagulants, like the orally available direct thrombin inhibitor (DTI) dabigatran etexilate, have recently been introduced… Expand
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Highly Cited
2010
Highly Cited
2010
The HIT Expert Probability (HEP) Score: a novel pre-test probability model for heparin-induced thrombocytopenia based on broad expert opinion.
BACKGROUND The diagnosis of heparin-induced thrombocytopenia (HIT) is challenging. Over-diagnosis and over-treatment are common… Expand
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Review
2010
Review
2010
Antithrombotic treatment failures in antiphospholipid syndrome: the new anticoagulants?
Anticoagulation with oral vitamin K antagonists (VKA) is the mainstay of the treatment of venous and/or arterial thromboembolism… Expand
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2010
2010
The paradoxical stimulation by a reversible thrombin inhibitor of thrombin generation in plasma measured with thrombinography is caused by alpha-macroglobulin-thrombin.
BACKGROUND Thrombin generation (TG) in plasma can be monitored continuously with a fluorogenic thrombin substrate using… Expand
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Highly Cited
2008
Highly Cited
2008
Fondaparinux for the treatment of patients with acute heparin-induced thrombocytopenia.
Heparin-induced thrombocytopenia (HIT) is a life-threatening immune response to heparin that is associated with a high risk of… Expand
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Highly Cited
2007
Highly Cited
2007
The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects.
AIMS The novel direct thrombin inhibitor (DTI), dabigatran etexilate (Boehringer Ingelheim Pharma GmbH & Co. KG), shows potential… Expand
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Highly Cited
2007
Highly Cited
2007
In-vitro profile and ex-vivo anticoagulant activity of the direct thrombin inhibitor dabigatran and its orally active prodrug, dabigatran etexilate.
Dabigatran is a reversible and selective, direct thrombin inhibitor (DTI) undergoing advanced clinical development as its orally… Expand
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2003
2003
Effects of ximelagatran, an oral direct thrombin inhibitor, r-hirudin and enoxaparin on thrombin generation and platelet activation in healthy male subjects.
OBJECTIVES The effects of ximelagatran, an oral direct thrombin inhibitor (DTI), recombinant hirudin (r-hirudin) and enoxaparin… Expand
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Review
2003
Review
2003
A novel approach to thrombin inhibition.
The inability of the heparin-antithrombin complex to inhibit fibrin-bound thrombin limits the utility of heparin for treatment of… Expand
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