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Dihydropteroate Synthase

Known as: Synthetase, Dihydropteroate, Synthase, Dihydropteroate, Dihydropteroate Synthetase 
An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. EC 2.5.1.15.
National Institutes of Health

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Papers overview

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2017
2017
Development of antibacterial conjugates using sulfamethoxazole with monocyclic terpenes: A systematic medicinal chemistry based computational approach
Review
2007
Review
2007
Genotyping of Pneumocystis jiroveci Pneumonia in Italian AIDS Patients: Clinical Outcome Is Influenced by Dihydropteroate Synthase and Not by Internal Transcribed Spacer Genotype
Background:Two Pneumocystis jiroveci independent genomic regions, internal transcribed spacer (ITS) 1 and ITS2, and… 
2005
2005
Dihydropteroate Synthase and Novel Dihydrofolate Reductase Gene Mutations in Strains of Pneumocystis jirovecii from South Africa
ABSTRACT Dihydropteroate synthase (DHPS) gene mutations have raised concerns about emerging sulfonamide resistance in… 
Review
2001
Review
2001
Resistance to trimethoprim-sulfamethoxazole and modifications in genes coding for dihydrofolate reductase and dihydropteroate synthase in European Streptococcus pneumoniae isolates.
Sir, Trimethoprim and sulfamethoxazole are used extensively in combination as the drug co-trimoxazole. Both compounds interfere… 
Highly Cited
1999
Highly Cited
1999
Pyrimethamine-sulfadoxine efficacy and selection for mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase in Mali.
To assess pyrimethamine-sulfadoxine (PS) efficacy in Mali, and the role of mutations in Plasmodium falciparum dihydrofolate… 
1998
1998
Development and comparison of quantitative assays for the dihydropteroate synthetase codon 540 mutation associated with sulfadoxine resistance in Plasmodium falciparum
A point mutation in codon 540 of the dihydropteroate synthetase (dhps) gene affecting sulfadoxine resistance has previously been… 
Highly Cited
1997
Highly Cited
1997
Adaptation to sulfonamide resistance in Neisseria meningitidis may have required compensatory changes to retain enzyme function: kinetic analysis of dihydropteroate synthases from N. meningitidis…
Previously, the effects of three point mutations (at amino acid positions 31, 84, and 194) in the gene coding for a sulfonamide… 
Highly Cited
1991
Highly Cited
1991
Inhibition of Plasmodium falciparum dihydropteroate synthetase and growth in vitro by sulfa drugs
The Michaelis-Menten inhibitory constants (Kis) and the concentrations required for 50% inhibition of the Plasmodium falciparum… 
1985
1985
Monocyclic pteridine analogues. Inhibition of Escherichia coli dihydropteroate synthase by 6-amino-5-nitrosoisocytosines.
A variety of 5,6-disubstituted isocytosine derivatives were evaluated in vitro as inhibitors of dihydropteroate synthase from… 
Highly Cited
1975
Highly Cited
1975
Sulfonamide resistance mechanism in Escherichia coli: R plasmids can determine sulfonamide-resistant dihydropteroate synthases.
Several natural isolate E. coli strains highly resistant to sulfonamides and antibiotics are shown to contain a sulfonamide… 
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