Dihydropteroate Synthase

Known as: Synthetase, Dihydropteroate, Synthase, Dihydropteroate, Dihydropteroate Synthetase 
An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. EC 2.5.1.15.
National Institutes of Health

Papers overview

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2012
2012
The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the folate pathway of bacteria and primitive… (More)
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2009
2009
Dihydropteroate synthase (DHPS) is the target of the sulfonamide class of antibiotics and has been a validated antibacterial drug… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND The impact of Pneumocystis jirovecii (formerly P. carinii) dihydropteroate synthase (DHPS) gene mutations on morbidity… (More)
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Highly Cited
2000
Highly Cited
2000
The antifolate combination of pyrimethamine (PM) and sulfadoxine (SD) is the last affordable drug combination available for wide… (More)
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Highly Cited
2000
Highly Cited
2000
To determine factors associated with mutations in the Pneumocystis carinii dihydropteroate synthase (DHPS) gene, a prospective… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in… (More)
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Highly Cited
1998
Highly Cited
1998
We have exploited the recently developed ability to trans- fect the malaria parasite Plasmodium falciparum to investigate the… (More)
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Highly Cited
1997
Highly Cited
1997
Plasmodium falciparum causes the most severe form of malaria in humans. An important class of drugs in malaria treatment is the… (More)
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Highly Cited
1997
Highly Cited
1997
Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered. The identification of sulfanilamide… (More)
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Highly Cited
1994
Highly Cited
1994
Dihydropteroate synthase (H2Pte synthase) is the target of the sulfur-based antimalarial drugs, which are frequently used in… (More)
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