Dihydropteroate Synthase

Known as: Synthetase, Dihydropteroate, Synthase, Dihydropteroate, Dihydropteroate Synthetase 
An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. EC 2.5.1.15.
National Institutes of Health

Related topics

Related topics

8 relations

Narrower (1)

Fol1 protein, S cerevisiae
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
(More)

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Catalysis and sulfa drug resistance in dihydropteroate synthase.
The sulfonamide antibiotics inhibit dihydropteroate synthase (DHPS), a key enzyme in the folate pathway of bacteria and primitive… (More)
  • figure 1
  • figure 2
  • table 1
  • figure 3
Is this relevant?
2009
2009
Validation of Molecular Docking Programs for Virtual Screening against Dihydropteroate Synthase
Dihydropteroate synthase (DHPS) is the target of the sulfonamide class of antibiotics and has been a validated antibacterial drug… (More)
  • figure 1
  • figure 2
  • figure 4
  • figure 5
  • table 1
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations.
BACKGROUND The impact of Pneumocystis jirovecii (formerly P. carinii) dihydropteroate synthase (DHPS) gene mutations on morbidity… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Towards an understanding of the mechanism of pyrimethamine-sulfadoxine resistance in Plasmodium falciparum: genotyping of dihydrofolate reductase and dihydropteroate synthase of Kenyan parasites.
The antifolate combination of pyrimethamine (PM) and sulfadoxine (SD) is the last affordable drug combination available for wide… (More)
  • table 1
  • table 2
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Sulfa or sulfone prophylaxis and geographic region predict mutations in the Pneumocystis carinii dihydropteroate synthase gene.
To determine factors associated with mutations in the Pneumocystis carinii dihydropteroate synthase (DHPS) gene, a prospective… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P. carinii pneumonia.
BACKGROUND Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Allelic exchange at the endogenous genomic locus in Plasmodium falciparum proves the role of dihydropteroate synthase in sulfadoxine-resistant malaria.
We have exploited the recently developed ability to trans- fect the malaria parasite Plasmodium falciparum to investigate the… (More)
  • figure 1
  • table I
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum.
Plasmodium falciparum causes the most severe form of malaria in humans. An important class of drugs in malaria treatment is the… (More)
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase
Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered. The identification of sulfanilamide… (More)
Is this relevant?
Highly Cited
1994
Highly Cited
1994
Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to…
Dihydropteroate synthase (H2Pte synthase) is the target of the sulfur-based antimalarial drugs, which are frequently used in… (More)
Is this relevant?