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Dihydropteroate Synthase

Known as: Synthetase, Dihydropteroate, Synthase, Dihydropteroate, Dihydropteroate Synthetase 
An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. EC 2.5.1.15.
National Institutes of Health

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Review
2014
Review
2014
Abstract Recent advances in microbial genomics, synthetic organic chemistry and X-ray crystallography provided opportunities to… Expand
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Highly Cited
2009
Highly Cited
2009
Dihydropteroate synthase (DHPS) is the target of the sulfonamide class of antibiotics and has been a validated antibacterial drug… Expand
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in… Expand
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Highly Cited
1997
Highly Cited
1997
Plasmodium falciparum causes the most severe form of malaria in humans. An important class of drugs in malaria treatment is the… Expand
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Highly Cited
1997
Highly Cited
1997
Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered. The identification of sulfanilamide… Expand
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Highly Cited
1997
Highly Cited
1997
The gene encoding the dihydropteroate synthase of staphylococcus aureus has been cloned, sequenced and expressed in Escherichia… Expand
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Highly Cited
1997
Highly Cited
1997
Sulfadoxine/pyrimethamine (Fansidar) is widely used in Africa for treating chloroquine‐resistant falciparum malaria. To clarify… Expand
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Highly Cited
1994
Highly Cited
1994
Dihydropteroate synthase (H2Pte synthase) is the target of the sulfur-based antimalarial drugs, which are frequently used in… Expand
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Highly Cited
1994
Highly Cited
1994
The enzyme dihydropteroate synthetase (DHPS) from Plasmodium falciparum is involved in the mechanism of action of the sulfone… Expand
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Highly Cited
1979
Highly Cited
1979
Sulfonamides are known to compete with p-aminobenzoic acid for dihydropteroate synthase. Others have reported that some… Expand
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