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Dihydropteroate Synthase

Known as: Synthetase, Dihydropteroate, Synthase, Dihydropteroate, Dihydropteroate Synthetase 
An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. EC 2.5.1.15.
National Institutes of Health

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Papers overview

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Review
2014
Review
2014
Sulfa and trimethoprim-like drugs – antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors
Abstract Recent advances in microbial genomics, synthetic organic chemistry and X-ray crystallography provided opportunities to… 
Highly Cited
2012
Highly Cited
2012
Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase
Sulfa's Crystal View The sulfonamide antibiotics (sulfa drugs) have been used to treat infections for over 70 years; however… 
Highly Cited
2005
Highly Cited
2005
Severity and outcome of HIV-associated Pneumocystis pneumonia containing Pneumocystis jirovecii dihydropteroate synthase gene mutations
Background:The impact of Pneumocystis jirovecii (formerly P. carinii) dihydropteroate synthase (DHPS) gene mutations on morbidity… 
Review
2004
Review
2004
Dihydropteroate Synthase Gene Mutations in Pneumocystis and Sulfa Resistance
We review studies of dihydropteroate synthase gene mutations in Pneumocystis jirovecii and summarize the evidence for resistance… 
Highly Cited
1997
Highly Cited
1997
Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase
Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered. The identification of sulfanilamide… 
Highly Cited
1997
Highly Cited
1997
Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum.
Plasmodium falciparum causes the most severe form of malaria in humans. An important class of drugs in malaria treatment is the… 
Highly Cited
1997
Highly Cited
1997
Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization
Sulfadoxine/pyrimethamine (Fansidar) is widely used in Africa for treating chloroquine‐resistant falciparum malaria. To clarify… 
Highly Cited
1997
Highly Cited
1997
Dihydropteroate synthase polymorphisms in Pneumocystis carinii.
Sulfa drugs are widely used in the treatment and prophylaxis of Pneumocystis carinii pneumonia. The nucleotide sequences of the… 
Highly Cited
1997
Highly Cited
1997
Structure and function of the dihydropteroate synthase from Staphylococcus aureus.
The gene encoding the dihydropteroate synthase of staphylococcus aureus has been cloned, sequenced and expressed in Escherichia… 
Highly Cited
1979
Highly Cited
1979
The characteristics and significance of sulfonamides as substrates for Escherichia coli dihydropteroate synthase.
Sulfonamides are known to compete with p-aminobenzoic acid for dihydropteroate synthase. Others have reported that some… 
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