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Dihydropteroate Synthase

Known as: Synthetase, Dihydropteroate, Synthase, Dihydropteroate, Dihydropteroate Synthetase 
An enzyme that catalyzes the formation of dihydropteroate from p-aminobenzoic acid and dihydropteridine-hydroxymethyl-pyrophosphate. EC 2.5.1.15.
National Institutes of Health

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Fol1 protein, S cerevisiae
In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Papers overview

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Review
2014
Review
2014
Sulfa and trimethoprim-like drugs – antimetabolites acting as carbonic anhydrase, dihydropteroate synthase and dihydrofolate reductase inhibitors
Abstract Recent advances in microbial genomics, synthetic organic chemistry and X-ray crystallography provided opportunities to… Expand
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Highly Cited
2009
Highly Cited
2009
Validation of Molecular Docking Programs for Virtual Screening against Dihydropteroate Synthase
Dihydropteroate synthase (DHPS) is the target of the sulfonamide class of antibiotics and has been a validated antibacterial drug… Expand
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Highly Cited
1999
Highly Cited
1999
Effects of mutations in Pneumocystis carinii dihydropteroate synthase gene on outcome of AIDS-associated P carinii pneumonia
BACKGROUND Sulpha drugs are widely used for the treatment and long-term prophylaxis of Pneumocystis carinii pneumonia (PCP) in… Expand
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Highly Cited
1997
Highly Cited
1997
Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparum.
Plasmodium falciparum causes the most severe form of malaria in humans. An important class of drugs in malaria treatment is the… Expand
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Highly Cited
1997
Highly Cited
1997
Crystal structure of the anti-bacterial sulfonamide drug target dihydropteroate synthase
Sulfonamides were amongst the first clinically useful antibacterial agents to be discovered. The identification of sulfanilamide… Expand
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Highly Cited
1997
Highly Cited
1997
Structure and function of the dihydropteroate synthase from Staphylococcus aureus.
The gene encoding the dihydropteroate synthase of staphylococcus aureus has been cloned, sequenced and expressed in Escherichia… Expand
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Highly Cited
1997
Highly Cited
1997
Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization
Sulfadoxine/pyrimethamine (Fansidar) is widely used in Africa for treating chloroquine‐resistant falciparum malaria. To clarify… Expand
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Highly Cited
1994
Highly Cited
1994
Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to…
Dihydropteroate synthase (H2Pte synthase) is the target of the sulfur-based antimalarial drugs, which are frequently used in… Expand
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Highly Cited
1994
Highly Cited
1994
Primary structure and expression of the dihydropteroate synthetase gene of Plasmodium falciparum.
The enzyme dihydropteroate synthetase (DHPS) from Plasmodium falciparum is involved in the mechanism of action of the sulfone… Expand
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Highly Cited
1979
Highly Cited
1979
The characteristics and significance of sulfonamides as substrates for Escherichia coli dihydropteroate synthase.
Sulfonamides are known to compete with p-aminobenzoic acid for dihydropteroate synthase. Others have reported that some… Expand
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