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Delapril Hydrochloride

The hydrochloride salt of delapril, a lipophilic, non-sulfhydryl angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a… Expand
National Institutes of Health

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delapril

Papers overview

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2003
2003
Single oral dose pharmacokinetic interaction study of manidipine and delapril in healthy volunteers.
OBJECTIVE The objective of the study was to assess potential pharmacokinetic interactions between delapril, an angiotensin… Expand
2003
2003
Angiotensin II type 2 receptor inhibits prorenin processing in juxtaglomerular cells.
Long-term treatment with an angiotensin II type 1 receptor blocker (ARB) has been shown to decrease the plasma renin activity… Expand
2003
2003
Pharmacokinetics and tolerability of a new manidipine and delapril fixed oral combination in young and elderly subjects.
OBJECTIVES The aim of the present study was to compare the pharmacokinetic and pharmacodynamic properties of a fixed combination… Expand
2000
2000
Delapril versus manidipine in hypertensive therapy to halt the type-2-diabetes-mellitus-associated nephropathy.
Thirty-nine hypertensive patients with type 2 diabetes mellitus were followed under long-term treatment (mean, 20.7 months) with… Expand
1998
1998
Long-term effects of delapril hydrochloride on procollagen type III amino-terminal peptide, left ventricular mass and left ventricular function in hypertensive patients.
The long-term effect of delapril hydrochloride, a non-sulfhydryl angiotensin converting enzyme inhibitor, on serum concentrations… Expand
1994
1994
Anti‐hypertensive Effect of Oral Controlled‐release Microspheres Containing an ACE Inhibitor (Delapril Hydrochloride) in Rats
Abstract— An oral controlled‐release drug delivery system based on microspheres of polyglycerol esters of fatty acids (PGEFs… Expand
1992
1992
Renal and extra-renal renin gene expression in spontaneously hypertensive rats.
To study the effect of antihypertensive therapy on the regulation of renin gene expression, the levels of tissue renin messenger… Expand
1991
1991
Direct proof for local generation and release of angiotensin II in peripheral human vascular tissue.
Previously we reported that immunoreactive angiotensin II (Ang II) release from isolated perfused human umbilical veins was… Expand
1990
1990
Effect of delapril hydrochloride on angiotensin II release from isolated rat hind legs.
The effect of the newly developed angiotensin-converting enzyme (ACE) inhibitor, delapril hydrochrolide (CV-3317), on the release… Expand
1987
1987
Pharmacokinetics and acute effect on the renin-angiotensin system of delapril in patients with chronic renal failure.
The acute effect on the renin-angiotensin system and the pharmacokinetic properties of delapril, a new angiotensin converting… Expand
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