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DYRK2 gene

Known as: DUAL-SPECIFICITY TYROSINE PHOSPHORYLATION-REGULATED KINASE 2, DYRK2, dual specificity tyrosine phosphorylation regulated kinase 2 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Selectivity, cocrystal structures, and neuroprotective properties of leucettines, a family of protein kinase inhibitors derived from the marine sponge alkaloid leucettamine B.
DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and… 
Highly Cited
2012
Highly Cited
2012
DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells.
Dysregulation of the G(1)/S transition in the cell cycle contributes to tumor development. The oncogenic transcription factors c… 
2010
2010
Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors.
Highly Cited
2009
Highly Cited
2009
ATM Augments Nuclear Stabilization of DYRK2 by Inhibiting MDM2 in the Apoptotic Response to DNA Damage*
The tumor suppressor p53 is a transcription factor that regulates cell cycle, DNA repair, senescence, and apoptosis in response… 
Highly Cited
2008
Highly Cited
2008
Application of Active and Kinase-Deficient Kinome Collection for Identification of Kinases Regulating Hedgehog Signaling
Review
2008
Review
2008
Role for DYRK family kinases on regulation of apoptosis.
Highly Cited
2008
Highly Cited
2008
Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6
Polo kinases are known key regulators of cell divisions. Here we report a novel, non-cell division function for polo kinases in… 
Highly Cited
2005
Highly Cited
2005
DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans.
Highly Cited
2003
Highly Cited
2003
Gene amplification in esophageal adenocarcinomas and Barrett's with high-grade dysplasia.
PURPOSE The purpose of this study was to determine the frequency and overall contribution of specific gene amplification events… 
Highly Cited
2000
Highly Cited
2000
Specificity Determinants of Substrate Recognition by the Protein Kinase DYRK1A*
DYRK1A is a dual-specificity protein kinase that is thought to be involved in brain development. We identified a single… 
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