DUOX2 gene

Known as: NADPH oxidase/peroxidase DUOX2, nicotinamide adenine dinucleotide phosphate oxidase, LNOX2 
 
National Institutes of Health

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DUOX1 gene

Papers overview

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2015
2015
The gut microbiota engages different signaling pathways to induce Duox2 expression in the ileum and colon epithelium
The epithelium is a first line of defense against microorganisms in the gut. Reactive oxygen species (ROS) have an important role… (More)
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2010
2010
Compound heterozygosity for a novel hemizygous missense mutation and a partial deletion affecting the catalytic core of the H2O2-generating enzyme DUOX2 associated with transient congenital…
Dual oxidases (DUOX) 1 and 2 are components of the thyroid H(2)O(2)-generating system. H(2)O(2) is used by thyroperoxidase to… (More)
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Highly Cited
2009
Highly Cited
2009
DUOX2-derived reactive oxygen species are effectors of NOD2-mediated antibacterial responses.
Generation of microbicidal reactive oxygen species (ROS) is a pivotal protective component of the innate immune system in many… (More)
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Review
2009
Review
2009
Targeting and regulation of reactive oxygen species generation by Nox family NADPH oxidases.
Nox family NADPH oxidases serve a variety of functions requiring reactive oxygen species (ROS) generation, including… (More)
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2007
2007
Missense mutations of dual oxidase 2 (DUOX2) implicated in congenital hypothyroidism have impaired trafficking in cells reconstituted with DUOX2 maturation factor.
Dual oxidase 2 (DUOX2), a reduced NAD phosphate:O2 oxidoreductase flavoprotein, is a component of the thyrocyte H2O2 generator… (More)
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Highly Cited
2006
Highly Cited
2006
Identification of the maturation factor for dual oxidase. Evolution of an eukaryotic operon equivalent.
Dual oxidase 2 (DUOX2), an NADPH:O(2) oxidoreductase flavoprotein, is a component of the thyroid H(2)O(2) generator crucial for… (More)
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Highly Cited
2003
Highly Cited
2003
Dual oxidases represent novel hydrogen peroxide sources supporting mucosal surface host defense.
Lactoperoxidase (LPO) is an enzyme with antimicrobial properties present in saliva, milk, tears, and airway secretions. Although… (More)
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2003
2003
Effect of iodide on nicotinamide adenine dinucleotide phosphate oxidase activity and Duox2 protein expression in isolated porcine thyroid follicles.
Thyroperoxidase requires H(2)O(2) to catalyze the biosynthesis of thyroxine residues on thyroglobulin. Iodide inhibits the… (More)
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Highly Cited
2002
Highly Cited
2002
Inactivating mutations in the gene for thyroid oxidase 2 (THOX2) and congenital hypothyroidism.
BACKGROUND Several genetic defects are associated with permanent congenital hypothyroidism. Immunologic, environmental, and… (More)
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Highly Cited
2001
Highly Cited
2001
Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5.
gp91phox is the catalytic subunit of the respiratory burst oxidase, an NADPH-dependent, superoxide generating enzyme present in… (More)
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