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DPY19L2 gene

Known as: dpy-19 like 2 (C. elegans), spermatogenesis associated 34, DPY19-LIKE 2 
 
National Institutes of Health

Topic mentions per year

Topic mentions per year

2011-2017
024620112017

Papers overview

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2016
2016
Identification of a new DPY19L2 mutation and a better definition of DPY19L2 deletion breakpoints leading to globozoospermia.
STUDY HYPOTHESIS The purpose of this study was to analyze DPY19L2 sequence variants to investigate the mechanism leading to the… (More)
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2015
2015
Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.
We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia. Non-genetically characterized cases… (More)
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2015
2015
Subcellular localization of phospholipase Cζ in human sperm and its absence in DPY19L2-deficient sperm are consistent with its role in oocyte activation.
We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia (70%) and described that Dpy19l2… (More)
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2013
2013
DPY19L2 gene mutations are a major cause of globozoospermia: identification of three novel point mutations.
Globozoospermia, characterized by round-headed spermatozoa without acrosomes, is a rare and severe teratozoospermia causing… (More)
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2013
2013
Assisted oocyte activation overcomes fertilization failure in globozoospermic patients regardless of the DPY19L2 status.
STUDY QUESTION Does DPY19L2 status influence intracytoplasmic sperm injection (ICSI) outcomes with or without assisted oocyte… (More)
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2013
2013
Fine Characterisation of a Recombination Hotspot at the DPY19L2 Locus and Resolution of the Paradoxical Excess of Duplications over Deletions in the General Population
We demonstrated previously that 75% of infertile men with round, acrosomeless spermatozoa (globozoospermia) had a homozygous 200… (More)
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2012
2012
MLPA and sequence analysis of DPY19L2 reveals point mutations causing globozoospermia.
STUDY QUESTION Do DPY19L2 heterozygous deletions and point mutations account for some cases of globozoospermia? SUMMARY ANSWER… (More)
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2012
2012
Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots.
To date, mutations in two genes, SPATA16 and DPY19L2, have been identified as responsible for a severe teratozoospermia, namely… (More)
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2011
2011
DPY19L2 deletion as a major cause of globozoospermia.
Globozoospermia, characterized by round-headed spermatozoa, is a rare (< 0.1% in male infertile patients) and severe… (More)
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2011
2011
A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation.
An increasing number of couples require medical assistance to achieve a pregnancy, and more than 2% of the births in Western… (More)
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