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Globozoospermia is characterized by the presence of 100% acrosomeless round-headed spermatozoa in an ejaculate. Failed… Expand We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia. Non-genetically characterized cases… Expand BACKGROUND
Male infertility affects >20 million men worldwide and represents a major health concern. Although multifactorial… Expand Globozoospermia, characterized by round-headed spermatozoa without acrosomes, is a rare and severe teratozoospermia causing… Expand STUDY QUESTION
Does DPY19L2 status influence intracytoplasmic sperm injection (ICSI) outcomes with or without assisted oocyte… Expand Sperm-head elongation and acrosome formation, which take place during the last stages of spermatogenesis, are essential to… Expand To date, mutations in two genes, SPATA16 and DPY19L2, have been identified as responsible for a severe teratozoospermia, namely… Expand STUDY QUESTION
Do DPY19L2 heterozygous deletions and point mutations account for some cases of globozoospermia?
SUMMARY ANSWER… Expand An increasing number of couples require medical assistance to achieve a pregnancy, and more than 2% of the births in Western… Expand Globozoospermia, characterized by round-headed spermatozoa, is a rare (< 0.1% in male infertile patients) and severe… Expand