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DPY19L2 gene

Known as: dpy-19 like 2 (C. elegans), spermatogenesis associated 34, DPY19-LIKE 2 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.
We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia. Non-genetically characterized cases… 
Review
2015
Review
2015
Teratozoospermia: spotlight on the main genetic actors in the human.
BACKGROUND Male infertility affects >20 million men worldwide and represents a major health concern. Although multifactorial… 
2013
2013
DPY19L2 gene mutations are a major cause of globozoospermia: identification of three novel point mutations.
Globozoospermia, characterized by round-headed spermatozoa without acrosomes, is a rare and severe teratozoospermia causing… 
Highly Cited
2013
Highly Cited
2013
Assisted oocyte activation overcomes fertilization failure in globozoospermic patients regardless of the DPY19L2 status.
STUDY QUESTION Does DPY19L2 status influence intracytoplasmic sperm injection (ICSI) outcomes with or without assisted oocyte… 
Highly Cited
2012
Highly Cited
2012
Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots.
To date, mutations in two genes, SPATA16 and DPY19L2, have been identified as responsible for a severe teratozoospermia, namely… 
Highly Cited
2012
Highly Cited
2012
Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus
Sperm-head elongation and acrosome formation, which take place during the last stages of spermatogenesis, are essential to… 
Highly Cited
2012
Highly Cited
2012
MLPA and sequence analysis of DPY19L2 reveals point mutations causing globozoospermia.
STUDY QUESTION Do DPY19L2 heterozygous deletions and point mutations account for some cases of globozoospermia? SUMMARY ANSWER… 
Highly Cited
2011
Highly Cited
2011
A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation.
Highly Cited
2011
Highly Cited
2011
DPY19L2 deletion as a major cause of globozoospermia.
2006
2006
Duplication and relocation of the functional DPY19L2 gene within low copy repeats
BackgroundLow copy repeats (LCRs) are thought to play an important role in recent gene evolution, especially when they facilitate… 
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