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DPY19L2 gene
Known as:
dpy-19 like 2 (C. elegans)
, spermatogenesis associated 34
, DPY19-LIKE 2
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Dpy19l2-deficient globozoospermic sperm display altered genome packaging and DNA damage that compromises the initiation of embryo development.
Sandra Yassine
,
J. Escoffier
,
+10 authors
C. Arnoult
Molecular human reproduction
2015
Corpus ID: 11977486
We recently identified the DPY19L2 gene as the main genetic cause of human globozoospermia. Non-genetically characterized cases…
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Review
2015
Review
2015
Teratozoospermia: spotlight on the main genetic actors in the human.
C. Coutton
,
J. Escoffier
,
G. Martinez
,
C. Arnoult
,
P. Ray
Human reproduction update
2015
Corpus ID: 15841205
BACKGROUND Male infertility affects >20 million men worldwide and represents a major health concern. Although multifactorial…
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2013
2013
DPY19L2 gene mutations are a major cause of globozoospermia: identification of three novel point mutations.
Fuxi Zhu
,
F. Gong
,
G. Lin
,
G. Lu
Molecular human reproduction
2013
Corpus ID: 9291242
Globozoospermia, characterized by round-headed spermatozoa without acrosomes, is a rare and severe teratozoospermia causing…
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Highly Cited
2013
Highly Cited
2013
Assisted oocyte activation overcomes fertilization failure in globozoospermic patients regardless of the DPY19L2 status.
P. Kuentz
,
F. Vanden Meerschaut
,
+10 authors
S. Viville
Human reproduction
2013
Corpus ID: 16732041
STUDY QUESTION Does DPY19L2 status influence intracytoplasmic sperm injection (ICSI) outcomes with or without assisted oocyte…
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Highly Cited
2012
Highly Cited
2012
Globozoospermia is mainly due to DPY19L2 deletion via non-allelic homologous recombination involving two recombination hotspots.
E. Elinati
,
P. Kuentz
,
+27 authors
S. Viville
Human molecular genetics
2012
Corpus ID: 40040496
To date, mutations in two genes, SPATA16 and DPY19L2, have been identified as responsible for a severe teratozoospermia, namely…
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Highly Cited
2012
Highly Cited
2012
Absence of Dpy19l2, a new inner nuclear membrane protein, causes globozoospermia in mice by preventing the anchoring of the acrosome to the nucleus
V. Pierre
,
G. Martinez
,
+7 authors
C. Arnoult
Development
2012
Corpus ID: 23410020
Sperm-head elongation and acrosome formation, which take place during the last stages of spermatogenesis, are essential to…
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Highly Cited
2012
Highly Cited
2012
MLPA and sequence analysis of DPY19L2 reveals point mutations causing globozoospermia.
C. Coutton
,
R. Zouari
,
+16 authors
P. Ray
Human reproduction
2012
Corpus ID: 16904282
STUDY QUESTION Do DPY19L2 heterozygous deletions and point mutations account for some cases of globozoospermia? SUMMARY ANSWER…
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Highly Cited
2011
Highly Cited
2011
A recurrent deletion of DPY19L2 causes infertility in man by blocking sperm head elongation and acrosome formation.
R. Harbuz
,
R. Zouari
,
+26 authors
P. Ray
American journal of human genetics
2011
Corpus ID: 205329087
Highly Cited
2011
Highly Cited
2011
DPY19L2 deletion as a major cause of globozoospermia.
I. Koscinski
,
E. Elinati
,
+9 authors
S. Viville
American journal of human genetics
2011
Corpus ID: 20794876
2006
2006
Duplication and relocation of the functional DPY19L2 gene within low copy repeats
A. Carson
,
J. Cheung
,
S. Scherer
BMC Genomics
2006
Corpus ID: 635523
BackgroundLow copy repeats (LCRs) are thought to play an important role in recent gene evolution, especially when they facilitate…
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