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DPH5 gene
Known as:
HSPC143
, diphthamide biosynthesis 5
, CGI-30
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Genome‐wide DNA methylation investigation of glucocorticoid exposure within buccal samples
Patricia R Braun
,
Mai Tanaka-Sahker
,
+19 authors
G. Shinozaki
Psychiatry and clinical neurosciences
2019
Corpus ID: 73500102
Glucocorticoids play a major role in regulating the stress response, and an imbalance of glucocorticoids has been implicated in…
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2018
2018
QM/MM Studies of Dph5 - A Promiscuous Methyltransferase in the Eukaryotic Biosynthetic Pathway of Diphthamide
Johanna Hörberg
,
P. Saenz-Méndez
,
L. Eriksson
J. Chem. Inf. Model.
2018
Corpus ID: 49342201
Eukaryotic diphthine synthase, Dph5, is a promiscuous methyltransferase that catalyzes an extraordinary N, O-tetramethylation of…
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2017
2017
Influence of DPH1 and DPH5 Protein Variants on the Synthesis of Diphthamide, the Target of ADP-Ribosylating Toxins
Klaus Mayer
,
A. Schröder
,
Jérôme Schnitger
,
S. Stahl
,
U. Brinkmann
Toxins
2017
Corpus ID: 5472996
The diphthamide on eukaryotic translation elongation factor 2 (eEF2) is the target of ADP-ribosylating toxins and -derivatives…
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2015
2015
Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor
S. Stahl
,
Ana Rita da Silva Mateus Seidl
,
+10 authors
U. Brinkmann
Proceedings of the National Academy of Sciences
2015
Corpus ID: 7639072
Significance Diphthamide is a conserved modification on eukaryotic translation elongation factor 2 (eEF2). Analyses of…
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2013
2013
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network
S. Uthman
,
C. Bär
,
+5 authors
R. Schaffrath
PLoS genetics
2013
Corpus ID: 6775419
Diphthamide is a highly modified histidine residue in eukaryal translation elongation factor 2 (eEF2) that is the target for…
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2013
2013
A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene*
Huiqin Wei
,
T. Bera
,
+4 authors
I. Pastan
The Journal of Biological Chemistry
2013
Corpus ID: 24163972
Background: Some children with leukemia do not respond to an immunotoxin containing Pseudomonas exotoxin A. Results: We isolated…
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2010
2010
Reconstitution of diphthine synthase activity in vitro.
Xuling Zhu
,
J. Kim
,
Xiaoyang Su
,
Hening Lin
Biochemistry
2010
Corpus ID: 29534428
Diphthamide, the target of diphtheria toxin, is a unique posttranslational modification on eukaryotic and archaeal translation…
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Highly Cited
2008
Highly Cited
2008
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development
T. Webb
,
S. Cross
,
+5 authors
I. Jackson
Journal of Cell Science
2008
Corpus ID: 618230
The intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor…
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Highly Cited
2004
Highly Cited
2004
Identification of the Proteins Required for Biosynthesis of Diphthamide, the Target of Bacterial ADP-Ribosylating Toxins on Translation Elongation Factor 2
Shihui Liu
,
G. T. Milne
,
J. Kuremsky
,
G. Fink
,
S. Leppla
Molecular and Cellular Biology
2004
Corpus ID: 206832506
ABSTRACT Diphthamide, a posttranslational modification of translation elongation factor 2 that is conserved in all eukaryotes and…
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Highly Cited
1992
Highly Cited
1992
DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae.
L. Mattheakis
,
W. Shen
,
R. Collier
Molecular and cellular biology
1992
Corpus ID: 30350351
A mutant of Saccharomyces cerevisiae defective in the S-adenosylmethionine (AdoMet)-dependent methyltransferase step of…
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