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DPH5 gene

Known as: HSPC143, diphthamide biosynthesis 5, CGI-30 
National Institutes of Health

Papers overview

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2019
2019
Genome‐wide DNA methylation investigation of glucocorticoid exposure within buccal samples
Glucocorticoids play a major role in regulating the stress response, and an imbalance of glucocorticoids has been implicated in… 
2018
2018
QM/MM Studies of Dph5 - A Promiscuous Methyltransferase in the Eukaryotic Biosynthetic Pathway of Diphthamide
Eukaryotic diphthine synthase, Dph5, is a promiscuous methyltransferase that catalyzes an extraordinary N, O-tetramethylation of… 
2017
2017
Influence of DPH1 and DPH5 Protein Variants on the Synthesis of Diphthamide, the Target of ADP-Ribosylating Toxins
The diphthamide on eukaryotic translation elongation factor 2 (eEF2) is the target of ADP-ribosylating toxins and -derivatives… 
2015
2015
Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor
Significance Diphthamide is a conserved modification on eukaryotic translation elongation factor 2 (eEF2). Analyses of… 
2013
2013
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network
Diphthamide is a highly modified histidine residue in eukaryal translation elongation factor 2 (eEF2) that is the target for… 
2013
2013
A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene*
Background: Some children with leukemia do not respond to an immunotoxin containing Pseudomonas exotoxin A. Results: We isolated… 
2010
2010
Reconstitution of diphthine synthase activity in vitro.
Diphthamide, the target of diphtheria toxin, is a unique posttranslational modification on eukaryotic and archaeal translation… 
Highly Cited
2008
Highly Cited
2008
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development
The intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor… 
Highly Cited
2004
Highly Cited
2004
Identification of the Proteins Required for Biosynthesis of Diphthamide, the Target of Bacterial ADP-Ribosylating Toxins on Translation Elongation Factor 2
ABSTRACT Diphthamide, a posttranslational modification of translation elongation factor 2 that is conserved in all eukaryotes and… 
Highly Cited
1992
Highly Cited
1992
DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae.
A mutant of Saccharomyces cerevisiae defective in the S-adenosylmethionine (AdoMet)-dependent methyltransferase step of… 
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