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DPH5 gene

Known as: HSPC143, diphthamide biosynthesis 5, CGI-30 
 
National Institutes of Health

Papers overview

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2019
2019
Genome‐wide DNA methylation investigation of glucocorticoid exposure within buccal samples
Glucocorticoids play a major role in regulating the stress response, and an imbalance of glucocorticoids has been implicated in… Expand
2017
2017
Influence of DPH1 and DPH5 Protein Variants on the Synthesis of Diphthamide, the Target of ADP-Ribosylating Toxins
The diphthamide on eukaryotic translation elongation factor 2 (eEF2) is the target of ADP-ribosylating toxins and -derivatives… Expand
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2015
2015
Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor
Significance Diphthamide is a conserved modification on eukaryotic translation elongation factor 2 (eEF2). Analyses of… Expand
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2014
2014
Decoding the biosynthesis and function of diphthamide, an enigmatic modification of translation elongation factor 2 (EF2)
Diphthamide is a highly conserved modification of archaeal and eukaryal translation elongation factor 2 (EF2) and yet why cells… Expand
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2013
2013
The Amidation Step of Diphthamide Biosynthesis in Yeast Requires DPH6, a Gene Identified through Mining the DPH1-DPH5 Interaction Network
Diphthamide is a highly modified histidine residue in eukaryal translation elongation factor 2 (eEF2) that is the target for… Expand
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2013
2013
A Modified Form of Diphthamide Causes Immunotoxin Resistance in a Lymphoma Cell Line with a Deletion of the WDR85 Gene*
Background: Some children with leukemia do not respond to an immunotoxin containing Pseudomonas exotoxin A. Results: We isolated… Expand
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2010
2010
Reconstitution of diphthine synthase activity in vitro.
Diphthamide, the target of diphtheria toxin, is a unique posttranslational modification on eukaryotic and archaeal translation… Expand
Highly Cited
2008
Highly Cited
2008
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development
The intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor… Expand
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Highly Cited
2004
Highly Cited
2004
Identification of the Proteins Required for Biosynthesis of Diphthamide, the Target of Bacterial ADP-Ribosylating Toxins on Translation Elongation Factor 2
ABSTRACT Diphthamide, a posttranslational modification of translation elongation factor 2 that is conserved in all eukaryotes and… Expand
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Highly Cited
1992
Highly Cited
1992
DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae.
A mutant of Saccharomyces cerevisiae defective in the S-adenosylmethionine (AdoMet)-dependent methyltransferase step of… Expand
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