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DPH2 gene

Known as: DPH2, DPH2L2, DPH2 homolog 
 
National Institutes of Health

Papers overview

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2015
2015
Loss of diphthamide pre-activates NF-κB and death receptor pathways and renders MCF7 cells hypersensitive to tumor necrosis factor
Significance Diphthamide is a conserved modification on eukaryotic translation elongation factor 2 (eEF2). Analyses of… Expand
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2014
2014
Genetic Modifiers of Neurofibromatosis Type 1-Associated Café-au-Lait Macule Count Identified Using Multi-platform Analysis
Neurofibromatosis type 1 (NF1) is an autosomal dominant, monogenic disorder of dysregulated neurocutaneous tissue growth… Expand
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2011
2011
Pharmacokinetics and organ distribution of diarylheptanoid phytoestrogens from Curcuma comosa in rats
Curcuma comosa is widely used as a traditional herbal medicine for gynecological diseases in South East Asia. Previous studies… Expand
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Highly Cited
2010
Highly Cited
2010
Diphthamide biosynthesis requires an organic radical generated by an iron–sulphur enzyme
Archaeal and eukaryotic translation elongation factor 2 contain a unique post-translationally modified histidine residue called… Expand
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2010
2010
A Dominant-Negative Approach That Prevents Diphthamide Formation Confers Resistance to Pseudomonas Exotoxin A and Diphtheria Toxin
Diphtheria toxin (DT), Pseudomonas aeruginosa Exotoxin A (ETA) and cholix toxin from Vibrio cholerae share the same mechanism of… Expand
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Highly Cited
2008
Highly Cited
2008
Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development
The intracellular target of diphtheria toxin is a modified histidine residue, diphthamide, in the translation elongation factor… Expand
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Highly Cited
2004
Highly Cited
2004
Identification of the Proteins Required for Biosynthesis of Diphthamide, the Target of Bacterial ADP-Ribosylating Toxins on Translation Elongation Factor 2
ABSTRACT Diphthamide, a posttranslational modification of translation elongation factor 2 that is conserved in all eukaryotes and… Expand
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1998
1998
Cloning and localization of a human diphthamide biosynthesis-like protein-2 gene, DPH2L2.
Sequence analysis of the candidate tumor suppressor OVCA1 revealed extensive sequence identity and similarity to proteins from a… Expand
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1996
1996
A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3.
Chromosome 17p13.3 is frequently deleted in human ovarian carcinoma, and the 15 kb critical region of deletion may contain a… Expand
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1993
1993
Diphthamide synthesis in Saccharomyces cerevisiae: structure of the DPH2 gene.
A gene involved in diphthamide biosynthesis, DPH2, was cloned from Saccharomyces cerevisiae by complementation of a diphthamide… Expand
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