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Dock10, a guanine nucleotide exchange factor for the Rho GTPases Rac1 and Cdc42, affects cell morphology, membrane protrusive… Expand Tumor cells can engage in a process called collective invasion, in which cohesive groups of cells invade through interstitial… Expand Dock10 is one of the three members of the Dock-D family of Dock proteins, a class of guanine nucleotide exchange factors (GEFs… Expand Rho GTPases are crucial regulators of dendritic spine morphogenesis. However, a clear picture of the RhoGEFs activating Rho… Expand Design of efficient nonviral gene delivery systems is limited as a result of the rudimentary understanding of the specific… Expand During the progression of head and neck squamous cell carcinoma (HNSCC), the induction of an epithelial-mesenchymal transition… Expand BACKGROUND
Tumor cells can move in a three-dimensional (3D) environment in either mesenchymal-type or amoeboid modes. In… Expand The Dock or CZH proteins are a family of activators for Rho GTPase proteins. The Zizimin subfamily is composed of three members… Expand We used cDNA microarrays to study gene expression in fresh frozen papillary thyroid carcinoma (PTC) specimens. Seven clinically… Expand A novel superfamily of guanine nucleotide exchange factors for Rho GTPases includes DOCK180 and zizimin1. The zizimin subfamily… Expand